# US 11,998,517 B2 · Antimicrobial composition

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 11,998,517 B2
- Document ID: US11998517B2
- Status: Granted
- Kind: B2
- Application number: 17/140,760
- Filed: 2021-01-04
- Published: 2021-04-29
- Granted: 2024-06-04
- Earliest claimed: 2016-09-07
- Assignees: Rottapharm S.p.A.
- Applicants: Rottapharm SpA
- Inventors: Andrea Zanardi; Alessandra Cercaci; Ivan Montaldo; Joachim Maus
- Web page: https://patentgrep.com/patent/US11998517B2

## CPC

- A61K 31/19: Carboxylic acids, e.g. valproic acid (salicylic acid A61K31/60)
- A01N 31/02: Acyclic compounds
- A01N 37/36: containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
- A01N 65/22: Lamiaceae or Labiatae [Mint family], e.g. thyme, rosemary, skullcap, selfheal, lavender, perilla, pennyroyal, peppermint or spearmint
- A61K 8/345: {containing more than one hydroxy group}
- A61K 8/365: Hydroxycarboxylic acids; Ketocarboxylic acids
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 31/047: having two or more hydroxy groups, e.g. sorbitol
- A61K 31/17: having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine (isoureas, isothioureas A61K31/155; sulfonylureas A61K31/64)
- A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A61K 47/12: Carboxylic acids; Salts or anhydrides thereof
- A61P 31/10: Antimycotics
- A61Q 17/005: {Antimicrobial preparations}
- A61Q 19/10: Washing or bathing preparations
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

The invention relates to a composition having antimicrobial and hygroscopic properties and the composition comprises a carboxylic acid compound as well as at least one C3-C6 diol and at least one C8-C12 diol. The composition of the invention may be used for cleansing, disinfection, surface treatment, impregnation and for antimicrobial treatment. The composition is particularly useful for treatment of fungal infections of the nail (onychomycosis).

## Claims

### Claim 1

A composition comprising:
about 9 wt % of a solution of 90% w/w lactic acid,
about 1.0 wt % of decylene glycol,
about 18 wt % urea,
about 3 wt % of a 30% w/w NaOH solution,
about 0.05-0.1 wt % of a hydrolate selected from the group consisting of mint hydrolate,
oregano hydrolate, and thymus hydrolate;
and an amount of propylene glycol sufficient to bring the composition to 100 wt %.

### Claim 2 (depends on 1)

The composition of claim 1, wherein the hydrolate is mint hydrolate.

### Claim 3 (depends on 1)

The composition of claim 1, wherein the hydrolate is oregano hydrolate.

### Claim 4 (depends on 1)

The composition of claim 1, wherein the hydrolate is thymus hydrolate.