# US 11,998,514 B2 · Cannabidiol and active delivery systems

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- Number: US 11,998,514 B2
- Document ID: US11998514B2
- Status: Granted
- Kind: B2
- Application number: 17/324,720
- Filed: 2021-05-19
- Published: 2021-11-25
- Granted: 2024-06-04
- Earliest claimed: 2020-05-21
- Assignees: Elementis Specialties, Inc.
- Applicants: Elementis Specialties, Inc.
- Inventors: Joseph Anthony Lupia; Kimberly Burch; Wouter Ijdo
- Web page: https://patentgrep.com/patent/US11998514B2

## CPC

- A61K 31/658: {o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol}
- A61K 8/26: Aluminium; Compounds thereof
- A61K 8/37: Esters of carboxylic acids
- A61K 8/416: {Quaternary ammonium compounds (A61K8/35 takes precedence)}
- A61K 9/06: Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)}
- A61K 9/107: Emulsions {; Emulsion preconcentrates; Micelles (composition of emulsions A61K47/00)}
- A61K 31/07: Retinol compounds, e.g. vitamin A (retinoic acids A61K31/203)
- A61K 31/355: Tocopherols, e.g. vitamin E
- A61K 31/375: Ascorbic acid, i.e. vitamin C; Salts thereof
- A61K 31/593: 9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
- A61K 36/16: Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
- A61K 36/185: Magnoliopsida (dicotyledons)
- A61K 36/258: Panax (ginseng)
- A61K 36/28: Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K 36/3482: {Cannabis}
- A61K 36/42: Cucurbitaceae (Cucumber family)
- A61K 36/53: Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K 36/82: Theaceae (Tea family), e.g. camellia
- A61K 36/886: Aloeaceae (Aloe family), e.g. aloe vera
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61K 47/02: Inorganic compounds
- A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A61K 47/186: {Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide}
- A61K 47/22: Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
- A61K 47/44: Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin (synthetic glycerides, e.g. medium-chain triglycerides, A61K47/14)
- A61Q 19/00: Preparations for care of the skin
- A61K 2800/10: General cosmetic use
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

A cannabidiol (CBD) gelled delivery system comprising: a rheology modifier; an emollient; and one or more cannabidiols selected from the group consisting of a cannabidiol broad spectrum oil, a cannabidiol full spectrum oil, or a cannabidiol isolate. A CBD emulsified delivery system comprising: a rheology modifier; an emollient; a polyglyceryl ester surfactant; and one or more cannabidiols selected from the group consisting of a cannabidiol broad spectrum oil, a cannabidiol full spectrum oil, or a cannabidiol isolate. For such delivery systems, the cannabidiols contain less than 0.3 wt. % of tetrahydrocannabinol (THC) or the cannabidiols are substantially free of THC. An active gelled delivery system a rheology modifier; an emollient; and one or more actives. An active emulsified delivery system comprising: a rheology modifier; an emollient; a polyglyceryl ester surfactant; and one or more actives.

## Claims

### Claim 1

A cannabidiol gelled delivery composition, consisting essentially of:
1 wt. % to 20 wt. % of a rheology modifier;
50 wt. % to 90 wt. % of an emollient selected from the group consisting of hemisqualane, C9-12 alkane, jojoba oil, caprylic/capric triglyceride, coco caprylate/caprate, octyldodecanol, and mixtures thereof; and
2 wt. % to 40 wt. % of a cannabidiol selected from the group consisting of a cannabidiol broad spectrum oil, a cannabidiol full spectrum oil, a cannabidiol isolate and mixtures thereof,
wherein the rheology modifier is an organoclay, which is a smectite clay exchanged with a quaternary ammonium cation having a formula of [N—R1R2R3R4]+, and
wherein:
R1 comprises a group selected from (i) linear or branched aliphatic, aralkyl, or aromatic hydrocarbon groups having from 8 to 30 carbon atoms or (ii) alkyl or alkyl-ester groups having 8 to 30 carbon atoms; and
R2, R3 and R4 are independently selected from the group consisting of linear or branched aliphatic, aralkyl and aromatic groups having from 1 to about 30 carbon atoms.

### Claim 2 (depends on 1)

The cannabidiol gelled delivery composition of claim 1, wherein the cannabidiol consists essentially of less than 0.3 wt. % of tetrahydrocannabinol or is substantially free of tetrahydrocannabinol.

### Claim 3 (depends on 1)

The cannabidiol gelled delivery composition of claim 1, wherein the quaternary ammonium cation is selected from the group consisting of (i) dimethyldialkyl ammonium cation wherein the alkyl hydrocarbon group has a number of carbon atoms selected from the group consisting of 8 to 30 carbon atoms and 12 to 22 carbon atoms; (ii) benzyldimethylalkyl ammonium cation, wherein the alkyl hydrocarbon group has a number of carbon atoms selected from the group consisting of 8 to 30 carbon atoms and 12 to 22 carbon atoms, and (iii) a combination thereof.

### Claim 4 (depends on 1)

The cannabidiol gelled delivery composition of claim 1, wherein the rheology modifier is used at 5 wt. % to 20 wt. %.