# US 11,998,439 B2 · Biodegradable vascular grafts > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,998,439 B2 - Document ID: US11998439B2 - Status: Granted - Kind: B2 - Application number: 16/793,355 - Filed: 2020-02-18 - Published: 2020-06-11 - Granted: 2024-06-04 - Earliest claimed: 2015-06-19 - Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education - Applicants: University of Pittsburgh—Of the Commonwealth System of Higher Education - Inventors: Robert Andrew Allen; Chelsea Elizabeth Stowell; Yadong Wang - Web page: https://patentgrep.com/patent/US11998439B2 ## CPC - A61F 2/07: Stent-grafts - A61F 2/06: Blood vessels - A61L 27/14: Macromolecular materials - A61L 27/18: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds - A61L 27/222: {Gelatin} - A61L 27/507: {for artificial blood vessels (apparatus for applying cells on a blood vessel prosthesis A61F2/062)} - A61L 27/54: Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)} - A61L 27/58: Materials at least partially resorbable by the body - D01D 5/0076: {characterised by the collecting device, e.g. drum, wheel, endless belt, plate or grid (D01D5/0046 takes precedence)} - D01D 5/0084: {Coating by electro-spinning, i.e. the electro-spun fibres are not removed from the collecting device but remain integral with it, e.g. coating of prostheses} - D01F 11/04: of synthetic polymers - A61L 27/225: {Fibrin; Fibrinogen} - A61L 27/24: Collagen - D01D 5/0007: {Electro-spinning (non-woven fabrics produced by electro-spinning D04H1/728)} - A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C) - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) - D01D: MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS - D01F: CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS ## Abstract A method of fabricating a vascular graft that includes preparing a biodegradable polyester electrospun tubular core; applying an adhesive composition comprising poly(lactide) copolymer to an outer surface of the biodegradable polyester electrospun tubular core; and surrounding the adhesive-applied biodegradable polyester electrospun tubular core with a polyester sheath. ## Claims ### Claim 1 A method of fabricating a vascular graft, comprising: preparing a biodegradable polyester electrospun tubular core; applying an adhesive composition comprising poly(lactide) copolymer to an outer surface of the biodegradable polyester electrospun tubular core; and surrounding the adhesive-applied biodegradable polyester electrospun tubular core with a polyester sheath, wherein the poly(lactide) copolymer adhesive composition has a biodegradation rate that is between the biodegradation rate of the polyester electrospun tubular core and the biodegradation rate of the polyester sheath. ### Claim 2 (depends on 1) The method of claim 1, wherein the adhesive composition further comprises dichloromethane, acetone, tetrahydrofuran, an alcohol, dimethylformamide, or a blend thereof. ### Claim 3 (depends on 1) The method of claim 1, wherein the poly(lactide) copolymer is selected from poly(lactide-co-caprolactone), poly(D,L-lactide-co-caprolactone), poly(D, L-lactide-co-glycolide), poly(L-lactide-co-glycolide), poly(L-lactide-co-caprolactone -co-glycolide), or a mixture thereof. ### Claim 4 (depends on 1) The method of claim 1, wherein the poly(lactide) copolymer comprises poly(L-lactide-co-ε-caprolactone). ### Claim 5 (depends on 1) The method of claim 1, wherein the poly(lactide) copolymer adhesive composition penetrates into at least a portion of the polyester sheath. ### Claim 6 (depends on 1) The method of claim 1, wherein the biodegradable polyester electrospun tubular core comprises poly(glycerol sebacate) (PGS). ### Claim 7 (depends on 1) The method of claim 1, wherein the biodegradable polyester sheath comprises poly(caprolactone) (PCL). ### Claim 8 (depends on 1) The method of claim 1, further comprising coating a thromboresistant agent on an inner lumen surface of the biodegradable polyester tubular core. ### Claim 9 (depends on 8) The method of claim 8, wherein the thromboresistant agent comprises heparin. ### Claim 10 (depends on 1) The method of claim 1, wherein the polyester outer sheath is a polyester electrospun sheath. ### Claim 11 (depends on 3) The method of claim 3, wherein the biodegradable polyester electrospun tubular core comprises poly(glycerol sebacate) (PGS), and the biodegradable polyester sheath comprises poly(caprolactone) (PCL). ### Claim 12 (depends on 1) The method of claim 1, wherein the poly(lactide) copolymer adhesive composition has an elastic modulus of about 100 kPa to about 10 MPa. ### Claim 13 (depends on 1) The method of claim 1, wherein the poly(lactide) copolymer adhesive composition has a strain recovery of at least 80% at 10% strain. ### Claim 14 (depends on 12) The method of claim 12, wherein the poly(lactide) copolymer adhesive composition has a strain recovery of at least 80% at 10% strain. ### Claim 15 (depends on 1) The method of claim 1, wherein the amount of poly(lactide) copolymer adhesive composition applied to the outer surface of the biodegradable polyester electrospun tubular core is 50-1000 μl per cm2. ### Claim 16 A method of fabricating a vascular graft, comprising: preparing a biodegradable polyester electrospun tubular core; applying an adhesive composition comprising poly(lactide) copolymer to an outer surface of the biodegradable polyester electrospun tubular core; and surrounding the adhesive-applied biodegradable polyester electrospun tubular core with a polyester sheath, wherein the poly(lactide) copolymer adhesive composition has an elastic modulus of about 100 kPa to about 10 MPa. ### Claim 17 A method of fabricating a vascular graft, comprising: preparing a biodegradable polyester electrospun tubular core; applying an adhesive composition comprising poly(lactide) copolymer to an outer surface of the biodegradable polyester electrospun tubular core; and surrounding the adhesive-applied biodegradable polyester electrospun tubular core with a polyester sheath, wherein the poly(lactide) copolymer adhesive composition has a strain recovery of at least 80% at 10% strain. ### Claim 18 A method of fabricating a vascular graft, comprising: preparing a biodegradable polyester electrospun tubular core; applying an adhesive composition comprising poly(lactide) copolymer to an outer surface of the biodegradable polyester electrospun tubular core; and surrounding the adhesive-applied biodegradable polyester electrospun tubular core with a polyester sheath, wherein the amount of poly(lactide) copolymer adhesive composition applied to the outer surface of the biodegradable polyester electrospun tubular core is 50-1000 μl per cm2. ### Claim 19 (depends on 16) The method of claim 16, wherein the biodegradable polyester electrospun tubular core comprises poly(glycerol sebacate) (PGS), and the biodegradable polyester sheath comprises poly(caprolactone) (PCL). ### Claim 20 (depends on 17) The method of claim 17, wherein the biodegradable polyester electrospun tubular core comprises poly(glycerol sebacate) (PGS), and the biodegradable polyester sheath comprises poly(caprolactone) (PCL). ### Claim 21 (depends on 18) The method of claim 18, wherein the biodegradable polyester electrospun tubular core comprises poly(glycerol sebacate) (PGS), and the biodegradable polyester sheath comprises poly(caprolactone) (PCL).