# US 11,998,436 B2 · System for treating embolism and associated devices and methods > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,998,436 B2 - Document ID: US11998436B2 - Status: Granted - Kind: B2 - Application number: 18/329,414 - Filed: 2023-06-05 - Published: 2023-10-05 - Granted: 2024-06-04 - Earliest claimed: 2018-08-13 - Assignees: Inari Medical, Inc. - Applicants: Inari Medical, Inc. - Inventors: Ben Merritt; Jacqueline Macias; Brian Michael Strauss; Thomas Tu; John Coleman Thress; Paul Lubock - Web page: https://patentgrep.com/patent/US11998436B2 ## CPC - A61F 2/01: Filters implantable into blood vessels - A61B 17/12109: {in a blood vessel} - A61M 1/815: {the barrel serving as aspiration container, e.g. in a breast pump} - A61M 1/84: {Drainage tubes; Aspiration tips (for negative pressure wound therapy A61M1/90; for surgical cutting instruments A61B17/32)} - A61B 17/221: Gripping devices in the form of loops or baskets {for gripping calculi or similar types of obstructions (surgical snare instruments A61B17/32056)} - A61B 2017/22034: {for gripping the obstruction or the tissue part from inside} - A61B 2017/22079: {with suction of debris} - A61B 2017/2212: {having a closed distal end, e.g. a loop} - A61B 2217/005: with suction drainage system - A61M 1/0281: {Apparatus for treatment of blood or blood constituents prior to transfusion, e.g. washing, filtering or thawing} - A61M 1/79: {Filters for solid matter (specially adapted for dental use A61C17/065)} - A61M 25/10: Balloon catheters ({A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02;} inflatable balloons for placing stents or stent-grafts A61F2/958 {; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00}) - A61M 2205/7545: for solid matter, e.g. microaggregates - A61M 2210/12: Blood circulatory system - A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract Systems and methods for the intravascular treatment of clot material within a blood vessel of a human patient are disclosed herein. A method in accordance with embodiments of the present technology can include, for example, positioning a distal portion of a catheter proximate to the clot material within the blood vessel. The method can further include coupling a pressure source to the catheter via a tubing subsystem including a valve or other fluid control device and, while the valve is closed, activating the pressure source to charge a vacuum. The valve can then be opened to apply the vacuum to the catheter to thereby aspirate at least a portion of the clot material from the blood vessel and into the catheter. ## Claims ### Claim 1 A method for the treatment of clot material within a vasculature of a patient, the method comprising: positioning an aspiration catheter at least partially within the vasculature proximate to the clot material; fluidly coupling a first chamber to an aspiration pump; fluidly coupling the first chamber to a second chamber distal of the first chamber; positioning a filter within the second chamber; selectively fluidly coupling the aspiration catheter to the second chamber via a user-actuatable valve positioned between the second chamber and the aspiration catheter; with the valve closed to inhibit fluid flow from the aspiration catheter to the second chamber, generating negative pressure in the first and second chambers; after generating the negative pressure, opening the valve via a user actuation such that fluid flow at least partially from the second chamber into the first chamber causes rapid aspiration of blood and at least a portion of the clot material into the second chamber, wherein the filter is configured to filter the blood from the portion of the clot material; and reintroducing the filtered blood into the vasculature of the patient. ### Claim 2 (depends on 1) The method of claim 1 wherein reintroducing the filtered blood into the patient includes directing the filtered blood distally through the aspiration catheter. ### Claim 3 (depends on 1) The method of claim 1 wherein the clot material comprises a pulmonary embolism. ### Claim 4 (depends on 1) The method of claim 1 wherein the clot material comprises a deep vein thrombus. ### Claim 5 (depends on 1) The method of claim 1 wherein the method further comprises selectively providing fluid access to a lumen of the aspiration catheter via a hemostasis valve fluidly coupled to the lumen of the aspiration catheter. ### Claim 6 (depends on 5) The method of claim 5 wherein the second chamber, the aspiration catheter, and the hemostasis valve form a coupled assembly. ### Claim 7 (depends on 6) The method of claim 6 wherein the second chamber is removably carried by the coupled assembly. ### Claim 8 (depends on 5) The method of claim 5 wherein the method further comprises advancing a second catheter at least partially through the hemostasis valve and the lumen of the aspiration catheter. ### Claim 9 (depends on 8) The method of claim 8 wherein advancing the second catheter at least partially through the hemostasis valve includes sliding the second catheter through a lumen of a tubular member of the hemostasis valve, wherein the hemostasis valve further comprises a filament extending at least partially around the tubular member, and wherein the filament is moveable between (a) a first position wherein the filament circumferentially constricts the lumen to create a seal around the second catheter and (b) a second position wherein the filament is moved to at least partially open the lumen. ### Claim 10 (depends on 1) The method of claim 1 wherein the second chamber is removably coupled between the aspiration pump and the aspiration catheter. ### Claim 11 (depends on 1) The method of claim 1 wherein the first chamber has a first volume, and wherein the second chamber has a second volume smaller than the first volume. ### Claim 12 (depends on 1) The method of claim 1 wherein reintroducing the filtered blood into the patient includes directing the filtered blood distally through a catheter separate from the aspiration catheter. ### Claim 13 (depends on 1) The method of claim 1 wherein the method further comprises removing the filter from within the second chamber; and clearing the portion of the clot material from within the second chamber. ### Claim 14 (depends on 1) The method of claim 1 wherein positioning the aspiration catheter at least partially within the vasculature proximate to the clot material includes positioning a distal end portion of the aspiration catheter proximal to the clot material. ### Claim 15 (depends on 1) The method of claim 1 wherein the clot material comprises a pulmonary embolism or deep vein thrombosis.