# US 11,993,808 B2 · Experimental apparatus for biochip

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 11,993,808 B2
- Document ID: US11993808B2
- Status: Granted
- Kind: B2
- Application number: 17/040,306
- Filed: 2020-04-07
- Published: 2021-05-20
- Granted: 2024-05-28
- Earliest claimed: 2019-05-06
- Assignees: Beijing BOE Technology Development Co., Ltd.; Boe Technology Group Co., Ltd.
- Applicants: Beijing Boe Technology Development Co., Ltd.; Boe Technology Group Co., Ltd.
- Inventors: Defeng Mao
- Web page: https://patentgrep.com/patent/US11993808B2

## CPC

- C12Q 1/6837: using probe arrays or probe chips (C12Q1/6874 takes precedence)
- B01L 3/502: {with fluid transport, e.g. in multi-compartment structures}
- B01L 7/00: Heating or cooling apparatus (autoclaves B01J3/04); Heat insulating devices
- B01L 9/52: {Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips}
- C12M 1/00: Apparatus for enzymology or microbiology
- B01L 2300/0636: Integrated biosensor, microarrays
- B01L 2300/0877: Flow chambers
- C12Q: MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- B01L: CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- C12M: APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; {APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS}

## Abstract

The present disclosure relates to an experimental apparatus for a biochip comprising: an enclosure within which a chamber configured to hold the biochip and a solution is disposed, wherein the enclosure is provided with an observation area, for observing a reaction process of the biochip and the solution in the chamber during an experiment.

## Claims

### Claim 1

An experimental apparatus for a biochip, comprising:
an enclosure within which a chamber configured to hold the biochip and a solution is disposed, wherein the enclosure is provided with an observation area, for observing a reaction process of the biochip and the solution in the chamber during an experiment,
the enclosure comprises:
a first pressing block, and
a second pressing block opposing the first pressing block,
wherein a side of the first pressing block facing the second pressing block is provided with a first reaction groove,
a side of the second pressing block facing the first pressing block is provided with a second reaction groove,
the first pressing block and the second pressing block are detachable and can be fixed together, and
the first reaction groove and the second reaction groove encircle to form the chamber,
wherein the experimental apparatus further comprises:
a connecting member, one end of which penetrates through the first pressing block and the second pressing block, and the other end of which is provided with a limiting part; and
a spring and a locking member, wherein the spring is sleeved on the connecting member, the locking member is fixed to the one end of the connecting member, and the spring presses against the first pressing block and the second pressing block to make the first pressing block and the second pressing block fixed together.

### Claim 2 (depends on 1)

The experimental apparatus for a biochip according to claim 1, wherein the enclosure is a split structure.

### Claim 3 (depends on 1)

The experimental apparatus for a biochip according to claim 1, wherein the enclosure further comprises:
a sealing cover mounted within one of the first reaction groove and the second reaction groove, and having an opening end facing the other of the first reaction groove and the second reaction groove, wherein the biochip is pressed against the other of the first reaction groove and the second reaction groove through the opening end of the sealing cover during the experiment, and the chamber formed by the encircling of the sealing cover and the biochip is used to define the solution.

### Claim 4 (depends on 3)

The experimental apparatus for a biochip according to claim 3, wherein the enclosure further comprises:
a mounting cover mounted within the one of the first reaction groove and the second reaction groove, an opening of the mounting cover facing the other of the first reaction groove and the second reaction groove, and the sealing cover being mounted within the mounting cover.

### Claim 5 (depends on 4)

The experimental apparatus for a biochip according to claim 4, wherein a positioning lug is arranged on the mounting cover, the positioning lug penetrates through one of the first pressing block and the second pressing block corresponding to the one of the first reaction groove and the second reaction groove to protrude out, a fitting lug is arranged on the corresponding one of the first pressing block and the second pressing block, and the positioning lug and the fitting lug are fixed together.

### Claim 6 (depends on 4)

The experimental apparatus for a biochip according to claim 4, wherein the sealing cover is made of transparent epoxy resin, the mounting cover is made of transparent glass, and the observation area is an observation window located on one of the first pressing block and the second pressing block corresponding to the one of the first reaction groove and the second reaction groove.

### Claim 7 (depends on 1)

The experimental apparatus for a biochip according to claim 1, further comprising:
a constant temperature module mounted on the enclosure and configured to keep a temperature within the chamber to be constant during the experiment.

### Claim 8 (depends on 7)

The experimental apparatus for a biochip according to claim 7, wherein the constant temperature module includes a heat sink mounted on a wall of the chamber and configured to keep the temperature within the chamber to be constant.

### Claim 9 (depends on 1)

The experimental apparatus for a biochip according to claim 1, wherein the enclosure is provided with a through hole in communication with the chamber.

### Claim 10 (depends on 9)

The experimental apparatus for a biochip according to claim 9, wherein the through hole includes at least one of a liquid inlet hole, a liquid outlet hole and a liquid feeding hole.

### Claim 11 (depends on 2)

The experimental apparatus for a biochip according to claim 2, further comprising:
a constant temperature module mounted on the enclosure and configured to keep a temperature within the chamber to be constant during the experiment.

### Claim 12 (depends on 3)

The experimental apparatus for a biochip according to claim 3, further comprising:
a constant temperature module mounted on the enclosure and configured to keep a temperature within the chamber to be constant during the experiment.

### Claim 13 (depends on 4)

The experimental apparatus for a biochip according to claim 4, further comprising:
a constant temperature module mounted on the enclosure and configured to keep a temperature within the chamber to be constant during the experiment.

### Claim 14 (depends on 5)

The experimental apparatus for a biochip according to claim 5, further comprising:
a constant temperature module mounted on the enclosure and configured to keep a temperature within the chamber to be constant during the experiment.

### Claim 15 (depends on 6)

The experimental apparatus for a biochip according to claim 6, further comprising:
a constant temperature module mounted on the enclosure and configured to keep a temperature within the chamber to be constant during the experiment.