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US 11,993,786 B2Granted
Methods and compositions for generating pacemaker cells
AssigneesTaipei Veterans General Hospital, National Yang Ming Chiao Tung University
InventorsYu-Feng Hu, Tze-Wen Chung, Shih-Ann Chen
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Abstract
Disclosed herein are methods and compositions for generating pacemaker cells from non-pacemaker cardiomyocytes. For example, the method includes the step of culturing the non-pacemaker cardiomyocytes with silk fibroin so that the silk fibroin induces the transformation of at least a portion thereof into pacemaker cells.
Claims3
A method of treating a subject suffering from cardiac arrhythmia, consisting of the step of administering to the heart of the subject an effective amount of a silk fibroin of Bombyx mori.
Dependencies are inferred from the claim text.