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US 11,993,640 B2Granted
Treating inflammatory lung disease
AssigneeThe United States Government as represented by the Department of Veterans Affairs
InventorsRobert M. Jackson, Andrew V. Schally, Renzhi Cai
Life of this patent
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Abstract
Described herein are compositions and methods for treating pulmonary fibrosis and cancer. The compositions include growth hormone releasing hormone peptides. The methods include reducing lung inflammation, lung scarring, reducing expression of T cell receptor complex genes as well as inhibiting tumor growth.
Claims4
A method of reducing lung inflammation, the method comprising:
- administering to a subject with pulmonary fibrosis a therapeutically effective amount of a growth hormone releasing hormone (GHRH) receptor antagonist, wherein the GHRH receptor antagonist is a peptide comprising the amino acid sequence:
- PhAC-Ada-Tyr D-Arg Asp Ala Ile 5FPhe Thr Ala Har Tyr(Me) His Orn Val Leu Abu Gln Leu Ser Ala His Orn Leu Leu Gln Asp Ile Nle D-Arg Har-NH2.
A method of reducing lung scarring, the method comprising:
- administering to a subject with pulmonary fibrosis a therapeutically effective amount of a growth hormone releasing hormone (GHRH) antagonist, wherein the GHRH receptor antagonist is a peptide comprising the amino acid sequence:
- PhAC-Ada-Tyr D-Arg Asp Ala Ile 5FPhe Thr Ala Har Tyr(Me) His Orn Val Leu Abu Gln Leu Ser Ala His Orn Leu Leu Gln Asp Ile Nle D-Arg Har-NH2.
A method of ameliorating one or more symptoms of pulmonary fibrosis, the method comprising:
- administering to a subject with pulmonary fibrosis a therapeutically effective amount of a growth hormone releasing hormone (GHRH) antagonist, wherein the GHRH receptor antagonist is a peptide comprising the amino acid sequence:
- PhAC-Ada-Tyr D-Arg Asp Ala Ile 5FPhe Thr Ala Har Tyr(Me) His Orn Val Leu Abu Gln Leu Ser Ala His Orn Leu Leu Gln Asp Ile Nle D-Arg Har-NH2.
Dependencies are inferred from the claim text.