Compositions and methods for modulating inflammatory responses
AssigneesDuke University, University of Massachusetts
InventorsFrancis Chan, Himani Nailwal
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Abstract
The present disclosure provides compositions and methods related to the modulation of the inflammation response activated by a host's immune system. In particular, the present disclosure provides novel inhibitors of proteins that exhibit pro-inflammatory activity (e.g., RIPK1, RIPK3, ZBP1, TRIF, CUL1, SKP1, and NF-κB, among others), as well as corresponding therapeutic compositions and methods of treatment using these inhibitors.
Claims4
A recombinant polypeptide comprising a sequence having at least 95% sequence identity relative to the full-length sequence of SEQ ID NO:
- 3, wherein the polypeptide does not comprise an F-box motif.
A pharmaceutical composition comprising:
- a recombinant polypeptide comprising a sequence having at least 95% sequence identity relative to the full-length sequence of SEQ ID NO:
- 3, wherein the polypeptide does not comprise an F-box motif;
- and
- a pharmaceutically acceptable carrier or excipient.
Dependencies are inferred from the claim text.