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US 11,993,591 B2Granted
Chromen-4-one derivatives for the treatment and prophylaxis of hepatitis B virus disease
AssigneeHoffmann-La Roche Inc.
InventorsSong Feng, Chungen Liang, Yongfu Liu, Xuefei Tan, Jun Wu, Jianping Wang
Life of this patent
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Abstract
The present invention provides novel compounds having the general formula (I) wherein R1 to R6, and m are as described herein, compositions including the compounds and methods of using the compounds.
Claims2
A compound selected from the group consisting of:
- 3-(2-(4-(8-chloro-4-oxo-chromene-2-carboxamido)-3-fluorophenoxy)ethoxy)cyclobutanecarboxylic acid;
- 3-(2-(4-(8-chloro-4-oxo-chromene-2-carboxamido)-3-methylphenoxy)ethoxy)cyclobutanecarboxylic acid;
- 6-chloro-N-(4-chloro-2-methylphenyl)-3-methyl-4-oxo-chromene-2-carboxamide;
- 3-(2-(4-(8-chloro-4-oxo-chromene-2-carboxamido)-3-(trifluoromethyl)phenoxy)ethoxy)cyclobutanecarboxylic acid;
- 8-chloro-4-oxo-N-(5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)-chromene-2-carboxamide;
- 3-(5-chloro-2-(8-chloro-4-oxo-chromene-2-carboxamido)phenoxy)cyclobutane-1-carboxylic acid;
- 8-chloro-N-(4-chloro-2-methylphenyl)-4-oxo-chromene-2-carboxamide;
- 8-chloro-N-(2,4-dichlorobenzyl)-4-oxo-chromene-2-carboxamide;
- N-(5-bromo-3-methylpyridin-2-yl)-8-chloro-4-oxo-chromene-2-carboxamide;
- 4-(5-chloro-2-(6,8-dichloro-4-oxo-chromene-2-carboxamido)phenoxy)butanoic acid;
- 8-chloro-N-(4-chloro-2-(trifluoromethyl)phenyl)-4-oxo-chromene-2-carboxamide;
- 6,8-dichloro-N-(4-chloro-2-methylphenyl)-4-oxo-chromene-2-carboxamide;
- 8-chloro-4-oxo-N-(o-tolyl)-chromene-2-carboxamide;
- 4-(8-chloro-4-oxo-chromene-2-carboxamido)-3-methylbenzoic acid;
- 2-(2-(4-(8-chloro-4-oxo-chromene-2-carboxamido)-3-methylphenoxy)ethoxy)acetic acid;
- 2-(5-chloro-2-(8-chloro-4-oxo-chromene-2-carboxamido)phenoxy)acetic acid;
- methyl 3-(8-chloro-4-oxo-chromene-2-carboxamido)-4-methylbenzoate;
- 2-(2-(5-chloro-2-(6,8-dichloro-4-oxo-chromene-2-carboxamido)phenoxy)ethoxy)acetic acid;
- N-(5-bromo-4-methylpyridin-2-yl)-8-chloro-4-oxo-chromene-2-carboxamide;
- 2-(2-(5-chloro-2-(8-chloro-4-oxo-chromene-2-carboxamido)phenoxy)ethoxy)acetic acid;
- methyl 5-chloro-2-(8-chloro-4-oxo-chromene-2-carboxamido)benzoate;
- methyl 4-((8-chloro-4-oxo-chromene-2-carboxamido)methyl)benzoate;
- methyl 4-(8-chloro-4-oxo-chromene-2-carboxamido)-3-methylbenzoate;
- N-(1-(4-bromophenyl)ethyl)-8-chloro-4-oxo-chromene-2-carboxamide;
- 8-chloro-N-(4-hydroxy-2-methylphenyl)-4-oxo-chromene-2-carboxamide;
- N-(5-bromo-3-methoxypyridin-2-yl)-8-chloro-4-oxo-chromene-2-carboxamide;
- 3-(2-(5-chloro-2-(8-chloro-4-oxo-chromene-2-carboxamido)phenoxy)ethoxy)cyclobutane-1-carboxylic acid;
- and
- ethyl 5-(8-chloro-4-oxo-chromene-2-carboxamido)-1,3,4-thiadiazole-2-carboxylate;
- or a pharmaceutically acceptable salt thereof.
27 more elements
Dependencies are inferred from the claim text.