# US 11,993,580 B1 · Methods of treating neurological disorders

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- Number: US 11,993,580 B1
- Document ID: US11993580B1
- Status: Granted
- Kind: B1
- Application number: 18/526,960
- Filed: 2023-12-01
- Published: 2024-07-25
- Granted: 2024-05-28
- Earliest claimed: 2022-12-02
- Assignees: Neumora Therapeutics, Inc.
- Applicants: Neumora Therapeutics, Inc.
- Inventors: Paul Dransfield; Dilinie Fernando; James Harvey; Brian Sparling; John Stellwagen; Zhihua Ma; Anne-Marie Beausoleil; Ryan Hudson
- Web page: https://patentgrep.com/patent/US11993580B1

## CPC

- C07D 401/04: directly linked by a ring-member-to-ring-member bond
- A61P 25/02: for peripheral neuropathies
- A61P 25/28: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present disclosure relates to compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein the variable are as described herein, and compositions and uses of same for treating neurological disorders.

## Claims

### Claim 1

A compound which is 5-(4-chlorophenyl)-2-isobutyl-6-(pyridin-4-yl)pyrimidin-4(3H)-one, or a pharmaceutically acceptable salt thereof, having the structure:
or a pharmaceutically acceptable salt thereof.

### Claim 2 (depends on 1)

The compound of claim 1, wherein the compound is 5-(4-chlorophenyl)-2-isobutyl-6-(pyridin-4-yl)pyrimidin-4(3H)-one.

### Claim 3

A compound which is 5-(4-chlorophenyl)-3-methyl-2-(methylamino)-6-(pyridin-4-yl)pyrimidin-4(3H)-one, or a pharmaceutically acceptable salt thereof, having the structure:
or a pharmaceutically acceptable salt thereof.

### Claim 4 (depends on 3)

The compound of claim 3, wherein the compound is 5-(4-chlorophenyl)-3-methyl-2-(methylamino)-6-(pyridin-4-yl)pyrimidin-4(3H)-one.

### Claim 5

A compound which is 5-(4-chloro-2-fluorophenyl)-2-isobutyl-6-(2-methylpyridin-4-yl)pyrimidin-4(3H)-one, or a pharmaceutically acceptable salt thereof, having the structure:
or a pharmaceutically acceptable salt thereof.

### Claim 6 (depends on 5)

The compound of claim 5, wherein the compound is 5-(4-chloro-2-fluorophenyl)-2-isobutyl-6-(2-methylpyridin-4-yl)pyrimidin-4(3H)-one.