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US 11,993,573 B2Granted
Chromane-substituted, tetrahydroquinoline-substituted and thiochromane-substituted heteroarotinoids as anti-cancer agents
AssigneeThe Board of Regents for Oklahoma State University
InventorsKenneth Darrell Berlin, Richard A. Bunce, Krishna Kumar Gnanasekaran, Field M. Watts, Jr., Donghua Howard Zhou
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Abstract
Chemical compounds that inhibit cancer cell growth are provided. The compounds are heteroarotinoids and derivatives thereof with oxygen, nitrogen or sulfur in chroman systems, tetrahydroquinoline systems, and tetrahydrothiochroman systems.
Claims4
A method of treating cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound
- selected from the group consisting of
- or a salt, solvate, or hydrate thereof.
A method of killing cancer cells, comprising contacting the cells with an amount of a compound
- selected from the group consisting of
- or a salt, solvate, or hydrate thereof.
Dependencies are inferred from the claim text.