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US 11,993,569 B2Granted
3-amino-4-halocyclopentene carboxylic acids as inactivators of aminotransferases
AssigneeNorthwestern University
InventorsRichard B. Silverman, Sida Shen
Life of this patent
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Abstract
Disclosed are cyclopentene compounds for use as inhibitors of aminotransferases such as gamma-aminobutyric acid (GABA) aminotransferase (AT) and/or ornithine aminotransferase (OAT). The disclosed cyclopentene compounds include 3-amino-4-halocyclopente carboxylic acid compounds which may be formulated in pharmaceutical composition for treating diseases and disorders associated with GABA-AT and/or OAT activity, including epilepsy, addiction, hepatocellular carcinoma (HCC), and non-small cell lung cancer (NSCLC).
Claims28
A compound having the following formula, a zwitterion form thereof, or a salt form thereof:
- wherein:
- X is halo or hydroxyl;
- Y is hydrogen or an amino-protecting group;
- and
- Z is hydrogen, alkyl, or a carboxyl protecting group.
2 more elements
Dependencies are inferred from the claim text.