Method and device for continuously synthesizing cyclopropane compounds

A method for continuously synthesizing a cyclopropane compound comprising the following steps:

• continuously performing a synthetic reaction of a diazomethane precursor in a first reactor, the reaction product of the first reactor flowing into a separator for stratification, the organic phase obtained by stratification overflowing into a second reactor, continuously consuming the diazomethane precursor in the second reactor to prepare diazomethane and performing an electron-rich monoolefin cyclopropanation reaction on diazomethane in situ so as to obtain the cyclopropane compound;
• the method for continuously synthesizing the cyclopropane compound further comprises a post-treatment step for the product of the second reactor;
• an electron-rich monoolefin compound and a palladium-containing catalyst are dissolved in tetrahydrofuran and continuously pumped into the second reactor by a fourth feed pump, while an aqueous potassium hydroxide solution is continuously pumped into the second reactor by a fifth feed pump;
• the electron-rich monoolefin compound has the following structure:
• wherein R1 represents hydrogen, t-butyl oxycarbonyl or carbobenzoxy;
• R2 represents hydrogen, phenyl, methyl or pyridyl;
• and R3 represents hydrogen, methyl or ethyl.