# US 11,992,703 B2 · Correlation of dose and dose rate information to volume for radiation treatment planning > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,992,703 B2 - Document ID: US11992703B2 - Status: Granted - Kind: B2 - Application number: 17/323,942 - Filed: 2021-05-18 - Published: 2021-12-23 - Granted: 2024-05-28 - Earliest claimed: 2020-06-23 - Assignees: Varian Medical Systems Particle Therapy GmbH; Varian Medical Systems, Inc.; Siemens Healthineers International AG - Applicants: Varian Medical Systems International AG.; Varian Medical Systems Particle Therapy GmbH & Co. KG; Varian Medical Systems, Inc. - Inventors: Pierre Lansonneur; Perttu Niemela; Viljo Petaja; Simon Busold; Michiko Rossi; Matti Sakari Ropo; Michael Folkerts; Jessica Perez; Christel Smith; Adam Harrington; Eric Abel; Lauri Halko - Web page: https://patentgrep.com/patent/US11992703B2 ## CPC - A61N 5/103: {Treatment planning systems} - A61N 5/1031: {using a specific method of dose optimization} - A61N 5/1071: {for verifying the dose delivered by the treatment plan} - A61N 2005/1074: {Details of the control system, e.g. user interfaces} - A61N 2005/1087: {Ions; Protons} - A61N 2005/1089: {Electrons} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) ## Abstract A method used for planning radiation treatment accessing information that includes calculated doses and calculated dose rates for sub-volumes in a treatment target, and also accessing information that includes values of a measure of the sub-volumes as a function of the calculated doses and the calculated dose rates. A graphical user interface includes a rendering that is based on the calculated doses, the calculated doses rates, and the values of the measure. ## Claims ### Claim 1 A computer system, comprising: a processor; a display device coupled to the processor; and a memory coupled to the processor, the memory storing instructions that, when executed by the processor, cause the computer system to access information including calculated doses and calculated dose rates for a plurality of sub-volumes in a volume in a treatment target, access information including values of a measure of the plurality of sub-volumes as a function of the calculated doses and the calculated dose rates, and display, via the display device, a graphical user interface (GUI) including, in a single rendering, a representation of the calculated doses, the calculated dose rates, and the values of the measure. ### Claim 2 (depends on 1) The computer system of claim 1, wherein the single rendering comprises a visualization of a dose-volume histogram as a first dimension of the GUI, a visualization of a dose rate-volume histogram as a second dimension of the GUI, and a visualization of the values of the measure as a third dimension of the GUI. ### Claim 3 (depends on 1) The computer system of claim 1, wherein the single rendering comprises a visualization of a calculated dose per sub-volume of the plurality of sub-volumes. ### Claim 4 (depends on 1) The computer system of claim 1, wherein the single rendering comprises a visualization of a calculated dose rate per sub-volume of the plurality of sub-volumes. ### Claim 5 (depends on 1) The computer system of claim 1, wherein the single rendering comprises a visualization of a value of the measure per sub-volume of the plurality of sub-volumes. ### Claim 6 A computer system, comprising: a processor; a display device coupled to the processor; and a memory coupled to the processor, the memory storing instructions that, when executed by the processor, cause the computer system to access information including calculated doses and calculated dose rates for a plurality of sub-volumes in a volume in a treatment target, access information including values of a measure of the plurality of sub-volumes as a function of the calculated doses and the calculated dose rates, and display, via the display device, a graphical user interface (GUI) including a rendering that is based on the calculated doses, the calculated dose rates, and the values of the measure, wherein the rendering includes a visualization of a prescription dose and a prescription dose rate. ### Claim 7 (depends on 1) The computer system of claim 1, wherein the GUI further comprises a visualization of normal tissue complication probability per sub-volume of the plurality of sub-volumes. ### Claim 8 (depends on 1) The computer system of claim 1, wherein the GUI further comprises a visualization of tumor control probability per sub-volume of the plurality of sub-volumes. ### Claim 9 (depends on 1) The computer system of claim 1, wherein the memory stores instructions that, when executed by the processor, cause the computer system to associate attribute values to elements of the single rendering corresponding to the calculated doses, the calculated dose rates, and the values of the measure; and display the elements according to the attribute values. ### Claim 10 (depends on 9) The computer system of claim 9, wherein the attribute values are values of attributes including at least one of color, pattern, gray-scale, alphanumeric text, or brightness. ### Claim 11 (depends on 1) The computer system of claim 1, wherein the single rendering includes a visualization of a prescription dose and a prescription dose rate. ### Claim 12 (depends on 1) The computer system of claim 1, wherein the single rendering further comprises isodose contour lines and isodose rate contour lines. ### Claim 13 A computer system, comprising: a processor; a display device coupled to the processor; and a memory coupled to the processor, the memory storing instructions that, when executed by the processor, cause the computer system to access information including calculated doses and calculated dose rates for a plurality of sub-volumes in a volume in a treatment target, access information including values of a measure of the plurality of sub-volumes as a function of the calculated doses and the calculated dose rates, and display, via the display device, a graphical user interface (GUI) including a rendering that is based on the calculated doses, the calculated dose rates, and the values of the measure, wherein the rendering includes isodose contour lines and isodose rate contour lines. ### Claim 14 A non-transitory computer-readable storage medium having computer-executable instructions for causing a computer system to perform a method used for planning radiation treatment, the method comprising: accessing a radiation treatment plan including a number of beams to be directed at and into a volume in a treatment target, directions of the beams, and a range of dose rates for each of the beams, wherein the volume includes a plurality of sub-volumes; calculating a dose per sub-volume of the plurality of sub-volumes using the number and directions of the beams and the range of dose rates; calculating a dose rate per sub-volume of the plurality of sub-volumes using the number and directions of the beams and the range of dose rates; determining, for different levels of dose and different levels of dose rate, a value of a measure of the sub-volumes that are calculated to receive at least a respective level of dose and at least a respective level of dose rate; and displaying, on a display device of the computer system, a graphical user interface (GUI) including a rendering of a representation of the calculated dose per sub-volume of the plurality of sub-volumes, the calculated dose rate per sub-volume of the plurality of sub-volumes, and the value of the measure of the sub-volumes that are calculated to receive at least the respective level of dose and at least the respective level of dose rate. ### Claim 15 (depends on 14) The non-transitory computer-readable storage medium of claim 14, wherein the rendering comprises a visualization of a dose-volume histogram as a first dimension of the GUI, a visualization of a dose rate-volume histogram as a second dimension of the GUI, and a visualization of the value of the measure as a third dimension of the GUI. ### Claim 16 (depends on 14) The non-transitory computer-readable storage medium of claim 14, wherein the rendering further comprises one or more of a visualization of a prescription dose and a prescription dose rate, a visualization of normal tissue complication probability per sub-volume of the plurality of sub-volumes, or a visualization of tumor control probability per sub-volume of the plurality of sub-volumes. ### Claim 17 (depends on 14) The non-transitory computer-readable storage medium of claim 14, wherein the method further comprises: associating attribute values to elements of the rendering corresponding to the calculated doses, the calculated dose rates, and the value of the measure; and displaying the elements according to the attribute values. ### Claim 18 (depends on 14) The non-transitory computer-readable storage medium of claim 14, wherein the rendering is a single rendering. ### Claim 19 A non-transitory computer-readable storage medium having computer-executable instructions for causing a computer system to perform a method used for planning radiation treatment, the method comprising: generating a dose-volume histogram (DVH) for a volume in a treatment target, wherein the DVH indicates a measure of the volume that receives a dose; generating a dose rate-volume histogram (DRVH) for the volume in the treatment target, wherein the DRVH indicates a measure of the volume that receives a dose rate; and displaying, on a display device of the computer system, a graphical user interface (GUI) including a combined rendering of the DVH and the DRVH, wherein the combined rendering visualizes a measure of the volume that is calculated to receive a given dose as a function of dose rate and also a measure of the volume that is calculated to receive a given dose rate as a function of dose. ### Claim 20 (depends on 19) The non-transitory computer-readable storage medium of claim 19, wherein the GUI comprises a visualization of the DVH as a first dimension of the GUI, a visualization of the DRVH as a second dimension of the GUI, and a visualization of values of the measure as a third dimension of the GUI. ### Claim 21 (depends on 19) The non-transitory computer-readable storage medium of claim 19, wherein the combined rendering comprises one or more of a visualization of calculated dose per sub-volume of a plurality of sub-volumes of the volume, a calculated dose rate per sub-volume of the plurality of sub-volumes, or a visualization of a value of the measure per sub-volume of the plurality of sub-volumes. ### Claim 22 (depends on 19) The non-transitory computer-readable storage medium of claim 19, wherein the combined rendering further comprises one or more of a visualization of a prescription dose and a prescription dose rate, a visualization of normal tissue complication probability per sub-volume of a plurality of sub-volumes of the volume, or a visualization of tumor control probability per sub-volume of the plurality of sub-volumes.