X-ray psoralen activated cancer therapy (X-PACT)

A method for treating a diseased site in a human or animal body, comprising:

• injecting in a diseased site a first pharmaceutical carrier including one or more phosphors which are capable of emitting ultraviolet or visible light into the body, wherein an amount of the phosphors in the first pharmaceutical carrier ranges from 0.1 to 0.66 milligrams of phosphor per cm3 of the volume of the diseased site;
• infusing the diseased site with a photoactivatable drug for intercalating into DNA of cells at the diseased site, wherein the photoactivatable drug is in a second pharmaceutical carrier, wherein a concentration of the photoactivatable drug in the second pharmaceutical carrier ranges from 10 μg/mL to 50 μg/mL, wherein the first pharmaceutical carrier and the second pharmaceutical carrier may be the same or different;
• applying an initiation energy from an initiation energy source comprising an energy source which is configured to irradiate the diseased site with at least one of x-rays, gamma rays, or electrons, to thereby initiate emission of said ultraviolet or visible light into the body;
• and
• controlling a dose of said initiation energy with a processor programmed to control said dose for production of said ultraviolet or visible light at the diseased site to activate the photoactivatable drug, wherein the infusion of the photoactivatable drug and the phosphors into the diseased site and the dose of said initiation energy produces a day-25 stable tumor volume;
• wherein the processor is programmed to apply the initiation energy to the diseased site in a pulsed manner, wherein the initiation energy is delivered in either (i) a radiograph mode where multiple pulses of a set mA and ms are delivered every 5-15 seconds, or (ii) a pulsed fluoroscopy mode at a maximum mA setting.