# US 11,992,687 B2 · System and method for rate modulated cardiac therapy utilizing a temperature sensor > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,992,687 B2 - Document ID: US11992687B2 - Status: Granted - Kind: B2 - Application number: 17/393,634 - Filed: 2021-08-04 - Published: 2021-11-25 - Granted: 2024-05-28 - Earliest claimed: 2019-03-22 - Assignees: Pacesetter, Inc. - Applicants: Pacesetter, Inc. - Inventors: Donald Chin - Web page: https://patentgrep.com/patent/US11992687B2 ## CPC - A61N 1/3655: {controlled by body or blood temperature} - A61N 1/3704: {Circuits specially adapted therefor, e.g. for sensitivity control} - A61N 1/3756: {Casings with electrodes thereon, e.g. leadless stimulators} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) ## Abstract Described herein are implantable medical systems, and methods for use therewith, that provide a temperature based rate response for a patient within which the implantable medical system is implanted. Such a method can include sensing a blood temperature signal indicative of a core body temperature of the patient, and producing a relative temperature signal based on the blood temperature signal. The method can further include producing a moving baseline temperature signal based on the relative temperature signal, producing a proportional response signal based on the relative temperature signal and the moving baseline temperature signal, and producing a sensor indicated rate response signal based on the proportional response signal and a base rate. The sensor indicated rate response signal can also be based on a dip response signal and/or a slope response signal. Additionally, a pacing rate is controlled based on the sensor indicated rate response signal. ## Claims ### Claim 1 For use with an implantable medical system, a method for providing a temperature based rate response for a patient within which the implantable medical system is implanted, the method comprising: sensing a blood temperature signal indicative of a core body temperature of the patient within which the implantable medical system is implanted; producing a relative temperature signal based on the blood temperature signal; producing a moving baseline temperature signal based on the relative temperature signal such that the moving baseline temperature signal follows the relative temperature signal during an initial drop in the blood temperature signal that occurs during an onset of activity, and the moving baseline temperature signal decays towards zero during an upswing in the blood temperature signal that follows the initial drop in the blood temperature signal; producing a proportional response signal based on the relative temperature signal and the moving baseline temperature signal; producing a sensor indicated rate response signal based on the proportional response signal and a base rate; and controlling a pacing rate of the implantable medical system based on the sensor indicated rate response signal. ### Claim 2 (depends on 1) The method of claim 1, wherein the producing the proportional response signal based on the relative temperature signal and the moving baseline temperature signal comprises: subtracting the moving baseline temperature signal from the relative temperature signal to produce a difference signal indicative of a difference between the relative temperature signal and the moving baseline temperature signal; and producing the proportional response signal based on positive portions of the difference signal. ### Claim 3 (depends on 2) The method of claim 2, wherein the producing the proportional response signal based on positive portions of the difference signal comprises: multiplying positive portions of the difference signal by a proportional gain value to thereby produce the proportional response signal; or applying a predetermined function to positive portions of the difference signal to thereby produce the proportional response signal. ### Claim 4 (depends on 1) The method of claim 1, wherein: the proportional response signal provides for an increase in the pacing rate, based on a difference between the relative temperature signal and the moving baseline temperature signal, during an upswing in the blood temperature signal that follows an initial drop in the blood temperature signal that occurs during an onset of activity; and the proportional response signal provides for a decrease in the pacing rate, based on the difference between the relative temperature signal and the moving baseline temperature signal, during a downswing in the blood temperature signal that occurs in response to a reduction or cessation in activity. ### Claim 5 (depends on 1) The method of claim 1, further comprising: producing at least one of a dip response signal or a slope response signal; and wherein the producing the sensor indicated rate response signal is also based on at least one of the dip response signal or the slope response signal; wherein the dip response signal provides for an increase in the pacing rate during an initial drop in the blood temperature signal that occurs during an onset of activity; and wherein the slope response signal provides for an increase in the pacing rate, based on a slope of the relative temperature signal, during an upswing in the blood temperature signal that follows an initial drop in the blood temperature signal. ### Claim 6 (depends on 5) The method of claim 5, wherein: the producing at least one of the dip response signal or the slope response signal comprises producing both the dip response signal and the slope response signal; and the producing the sensor indicated rate response signal comprises producing the sensor indicated rate response signal based on a combination of the proportional response signal, the dip response signal, the slope response signal, and the base rate. ### Claim 7 (depends on 6) The method of claim 6, wherein: the producing the sensor indicated rate response signal based on the combination of the proportional response signal, the dip response signal, the slope response signal, and the base rate comprises producing the sensor indicated rate response signal by summing the proportional response signal, the dip response signal, the slope response signal, and the base rate. ### Claim 8 (depends on 6) The method of claim 6, wherein the producing the dip response signal comprises: comparing the relative temperature signal to a dip threshold; providing a dip onset rate value to an input of an integrator while the relative temperature signal is less than the dip threshold; providing a dip decay rate value to the input of the integrator while the relative temperature signal is greater than the dip threshold; and using positive portions of a signal output by the integrator as the dip response signal. ### Claim 9 (depends on 6) The method of claim 6, wherein the producing the slope response signal comprises: producing a signal indicative of a positive slope of the relative temperature signal; and either multiplying the signal indicative of the positive slope of the relative temperature signal by a slope gain value to thereby produce the slope response signal, or applying a predetermined function to the signal indicative of the positive slope of the relative temperature signal to thereby produce the slope response signal. ### Claim 10 (depends on 9) The method of claim 9, wherein the producing the signal indicative of the positive slope of the relative temperature signal comprises: providing the relative temperature signal to a high pass filter (HPF) to thereby produce a signal indicative of a slope of the relative temperature signal, and providing an output of the HPF to a rectifier to thereby produce the signal indicative of the positive slope of the relative temperature signal; or determining a difference between two temporally different samples of the relative temperature signal, and producing the signal indicative of the positive slope of the relative temperature signal based on the difference. ### Claim 11 (depends on 1) The method of claim 1, wherein the producing the relative temperature signal based on the blood temperature signal comprises: producing a short term average (STA) of the blood temperature signal; producing a long term average (LTA) of the blood temperature signal; and producing the relative temperature signal by subtracting the LTA of the blood temperature signal from the STA of the blood temperature signal. ### Claim 12 (depends on 1) The method of claim 1, wherein the producing the sensor indicated rate response signal comprises: producing a rate adjustment signal based on the proportion response signal; adding the rate adjustment signal to a base rate to produce the sensor indicated rate response signal; and limiting at least one of a magnitude or a slew rate of the sensor indicated rate response signal. ### Claim 13 An implantable medical system, comprising: one or more pulse generators configured to selectively produce pacing pulses; one or more electrodes configured to deliver pacing pulses produced by at least one of the one or more pulse generators to a heart of a patient within which the implantable medical system is implanted; a temperature sensor configured to produce a blood temperature signal indicative of a core body temperature of the patient within which the implantable medical system is implanted; and a controller configured to: produce a relative temperature signal based on the blood temperature signal; produce a moving baseline temperature signal based on the relative temperature signal, wherein the moving baseline temperature signal follows the relative temperature signal during an initial drop in the blood temperature signal that occurs during an onset of activity, and the moving baseline temperature signal decays towards zero during an upswing in the blood temperature signal that follows the initial drop in the blood temperature signal; produce a proportional response signal based on the relative temperature signal and the moving baseline temperature signal; produce a sensor indicated rate response signal based on the proportional response signal and a base rate; and control delivery of the pacing pulses to thereby control a pacing rate based on the sensor indicated rate response signal. ### Claim 14 (depends on 13) The implantable medical system of claim 13, wherein the controller is configured to produce the proportional response signal based on the relative temperature signal and the moving baseline temperature signal by: subtracting the moving baseline temperature signal from the relative temperature signal to produce a difference signal indicative of a difference between the relative temperature signal and the moving baseline temperature signal; and producing the proportional response signal based on positive portions of the difference signal. ### Claim 15 (depends on 13) The implantable medical system of claim 13, wherein: the proportional response signal provides for an increase in the pacing rate, based on a difference between the relative temperature signal and the moving baseline temperature signal, during an upswing in the blood temperature signal that follows an initial drop in the blood temperature signal that occurs during an onset of activity; and the proportional response signal provides for a decrease in the pacing rate, based on the difference between the relative temperature signal and the moving baseline temperature signal, during a downswing in the blood temperature signal that occurs in response to a reduction or cessation in activity. ### Claim 16 (depends on 13) The implantable medical system of claim 13, wherein the controller is also configured to: produce at least one of a dip response signal or a slope response signal; and produce the sensor indicated rate response signal also based on at least one of the dip response signal or the slope response signal; wherein the dip response signal provides for an increase in the pacing rate during an initial drop in the blood temperature signal that occurs during an onset of activity; and wherein the slope response signal provides for an increase in the pacing rate, based on a slope of the relative temperature signal, during an upswing in the blood temperature signal that follows an initial drop in the blood temperature signal. ### Claim 17 (depends on 16) The implantable medical system of claim 16, wherein the controller is configured to: produce both the dip response signal and the slope response signal; and produce the sensor indicated rate response signal based on a combination of the proportional response signal, the dip response signal, the slope response signal, and the base rate. ### Claim 18 (depends on 17) The implantable medical system of claim 17, wherein the controller is configured to: compare the relative temperature signal to a dip threshold; provide a dip onset rate value to an input of an integrator while the relative temperature signal is less than the dip threshold; provide a dip decay rate value to the input of the integrator while the relative temperature signal is greater than the dip threshold; and use positive portions of a signal output by the integrator as the dip response signal. ### Claim 19 (depends on 17) The implantable medical system of claim 17, wherein the controller is configured to add the proportional response signal, the dip response signal, the slope response signal, and the base rate to produce the sensor indicated rate response signal, and limit at least one of a magnitude or a slew rate of the sensor indicated rate response signal. ### Claim 20 (depends on 13) The implantable medical system of claim 13, wherein the controller is configured to: produce a short term average (STA) of the blood temperature signal; produce a long term average (LTA) of the blood temperature signal; and produce the relative temperature signal by subtracting the LTA of the blood temperature signal from the STA of the blood temperature signal. ### Claim 21 For use with an implantable medical system, a method for providing a temperature based rate response for a patient within which the implantable medical system is implanted, the method comprising: sensing a blood temperature signal indicative of a core body temperature of the patient within which the implantable medical system is implanted; producing a relative temperature signal based on the blood temperature signal; producing a moving baseline temperature signal based on the relative temperature signal; producing a proportional response signal based on the relative temperature signal and the moving baseline temperature signal; producing a dip response signal and a slope response signal based on the relative temperature signal; producing a sensor indicated rate response signal based on a sum of the proportional response signal, the dip response signal, and the slope response signal; and controlling a pacing rate of the implantable medical system based on the sensor indicated rate response signal. ### Claim 22 (depends on 21) The method of claim 21, wherein: the dip response signal provides for an increase in the pacing rate during an initial drop in the blood temperature signal that occurs during an onset of activity; the slope response signal provides for an increase in the pacing rate, based on a slope of the relative temperature signal, during an upswing in the blood temperature signal that follows the initial drop in the blood temperature signal; the proportional response signal provides for an increase in the pacing rate, based on a difference between the relative temperature signal and the moving baseline temperature signal, during an upswing in the blood temperature signal that follows the initial drop in the blood temperature signal that occurs during the onset of activity; and the proportional response signal provides for a decrease in the pacing rate, based on the difference between the relative temperature signal and the moving baseline temperature signal, during a downswing in the blood temperature signal that occurs in response to a reduction or cessation in activity. ### Claim 23 (depends on 21) The method of claim 21, wherein the moving baseline temperature signal is produced based on the relative temperature signal such that the moving baseline temperature signal follows the relative temperature signal during an initial drop in the blood temperature signal that occurs during an onset of activity, and the moving baseline temperature signal decays towards zero during an upswing in the blood temperature signal that follows the initial drop in the blood temperature signal. ### Claim 24 (depends on 21) The method of claim 21, wherein the producing the sensor indicated rate response is signal is based on the sum of the proportional response signal, the dip response signal, and the slope response signal, also summed with a base rate.