# US 11,992,678 B2 · System and method for individualizing neuromodulation

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- Number: US 11,992,678 B2
- Document ID: US11992678B2
- Status: Granted
- Kind: B2
- Application number: 17/383,143
- Filed: 2021-07-22
- Published: 2021-11-11
- Granted: 2024-05-28
- Earliest claimed: 2017-11-17
- Assignees: Flow Neuroscience, Inc.
- Applicants: Flow Neuroscience, Inc.
- Inventors: Brett Wingeier; Randall Lin; Daniel Toker
- Web page: https://patentgrep.com/patent/US11992678B2

## CPC

- A61N 1/08: Arrangements or circuits for monitoring, protecting, controlling or indicating {(for external stimulators A61N1/3603; for implantable neurostimulators A61N1/36128; for heart stimulators A61N1/37; for defibrillators A61N1/3925)}
- A61N 1/0456: {Specially adapted for transcutaneous electrical nerve stimulation [TENS]}
- A61N 1/205: {for promoting a biological process}
- A61N 1/36025: {for treating a mental or cerebral condition}
- A61N 1/3603: {Control systems}
- A61B 5/16: Devices for psychotechnics (using teaching or educational appliances G09B1/00 - G09B7/00); Testing reaction times {; Devices for evaluating the psychological state}
- A61B 5/6803: {Head-worn items, e.g. helmets, masks, headphones or goggles}
- A61B 5/7275: {Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor}
- A61N 1/0476: {Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)}
- A61N 1/0484: {Garment electrodes worn by the patient}
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

A system for individualizing neuromodulation includes a neurostimulation device having a set of electrodes, and an application executing on a user device. Additionally or alternatively, the system can include any or all of: a sensor system, a head-securing mechanism, a remote server, storage, an accessory device, and any other suitable component. A method for individualizing neuromodulation includes determining a task of interest to a user; determining a user skill level associated with the task; determining a set of goals; determining an individualized neuromodulation program comprising a neurostimulation pattern; and delivering the neurostimulation pattern to the user. Additionally or alternatively, the method can include any or all of: determining user progress; displaying user progress; receiving user feedback; determining and/or adapting neuromodulation program based on user progress and/or user feedback; and any other suitable process.

## Claims

### Claim 1

A system for providing personalized neurostimulation to a user, the system comprising:
a neurostimulation device reversibly coupleable to a head region of the user, wherein the neurostimulation device is configured to deliver a personalized neurostimulation pattern to the head region; and
a processing subsystem in communication with the neurostimulation device, wherein the processing subsystem:
receives an input associated with the user;
determines a user-selected goal for the user based on the input and with a mapping;
determines the personalized neurostimulation pattern for the user based on the user-selected goal;
transmits the personalized neurostimulation pattern to the neurostimulation device for delivery;
determines a progress of the user toward the user-selected goal based on one or more additional inputs from the user; and
modifies the personalized neurostimulation pattern based on the progress of the user.

### Claim 2 (depends on 1)

The system of claim 1, further comprising a client application in communication with the processing subsystem,
wherein the input associated with the user is received at the client application.

### Claim 3 (depends on 2)

The system of claim 2, wherein the client application is executable on a mobile user device,
wherein at least a portion of the processing subsystem is arranged onboard the mobile user device.

### Claim 4 (depends on 2)

The system of claim 2, wherein the client application is in communication with a messaging platform,
wherein the input is determined based on a set of messages received from the user at the messaging platform.

### Claim 5 (depends on 1)

The system of claim 1, wherein the processing subsystem further receives a second input from the user in response to the delivery of the personalized neurostimulation pattern.

### Claim 6 (depends on 5)

The system of claim 5, wherein the processing subsystem determines the progress of the user toward the user-selected goal based on the second input.

### Claim 7 (depends on 1)

The system of claim 1, wherein the processing subsystem modifies the personalized neurostimulation pattern by modifying at least one of:
a set of locations of the neurostimulation device at which the personalized neurostimulation pattern is applied;
a waveform of the personalized neurostimulation pattern; and
an intensity of the personalized neurostimulation pattern.

### Claim 8 (depends on 7)

The system of claim 7, wherein the neurostimulation device comprises a set of multiple electrodes, wherein the processing subsystem modifies the personalized stimulation pattern by determining an updated subset of the set of multiple electrodes,
wherein the neurostimulation device further delivers the personalized neurostimulation pattern after modifying the personalized neurostimulation pattern through the updated subset.

### Claim 9 (depends on 1)

The system of claim 1, wherein the processing subsystem further transmits the personalized neurostimulation pattern after modifying the personalized neurostimulation pattern to the neurostimulation device for delivery.

### Claim 10 (depends on 1)

The system of claim 1, wherein the mapping is a lookup table.

### Claim 11

A method for providing personalized neurostimulation to a user, the method comprising:
receiving an input from the user;
determining a user-selected goal based on the input and with a mapping;
determining a personalized neurostimulation pattern for the user based on the user-selected goal;
transmitting the personalized neurostimulation pattern to a neurostimulation device such that the neurostimulation device delivers the personalized neurostimulation pattern to the user;
determining a progress of the user toward the user-selected goal based on one or more additional inputs from the user; and
modifying the personalized neurostimulation pattern based on the progress of the user.

### Claim 12 (depends on 11)

The method of claim 11, wherein the mapping comprises at least one of a decision tree and a lookup table.

### Claim 13 (depends on 12)

The method of claim 12, wherein the mapping is a lookup table.

### Claim 14 (depends on 12)

The method of claim 12, wherein the mapping comprises multiple mappings.

### Claim 15 (depends on 11)

The method of claim 11, wherein the input from the user is received at a client application executable on a user device.

### Claim 16 (depends on 15)

The method of claim 15, wherein the client application is in communication with a messaging platform,
wherein the input is associated with a set of messages received from the user at the messaging platform.

### Claim 17 (depends on 11)

The method of claim 11, further comprising receiving a second input from the user in response to delivering the personalized neurostimulation pattern to the user.

### Claim 18 (depends on 17)

The method of claim 17, wherein determining the progress of the user toward the user-selected goal is based on the second input.

### Claim 19 (depends on 11)

The method of claim 11, wherein modifying the personalized neurostimulation pattern comprises modifying at least one of:
a set of locations of the neurostimulation device at which the personalized neurostimulation pattern is applied;
a waveform of the personalized neurostimulation pattern; and
an intensity of the personalized neurostimulation pattern.

### Claim 20

A non-transitory processor-readable medium storing code representing instructions to be executed by a processor, the code comprising code to cause the processor to:
determine a user-selected goal based on an input from a user and with a mapping;
determine a personalized neurostimulation pattern for the user based on the user-selected goal;
transmit the personalized neurostimulation pattern to a neurostimulation device such that the neurostimulation device delivers the personalized neurostimulation pattern to the user;
determine a progress of the user toward the user-selected goal based on one or more additional inputs from the user; and
modify the personalized neurostimulation pattern based on the progress of the user.
