# US 11,992,640 B2 · Devices for applying a topical treatment

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 11,992,640 B2
- Document ID: US11992640B2
- Status: Granted
- Kind: B2
- Application number: 16/464,538
- Filed: 2017-11-28
- Published: 2020-12-10
- Granted: 2024-05-28
- Earliest claimed: 2016-11-28
- Applicants: The Jenex Corporation
- Inventors: Roberto Fia; Maurizio Battistuzzi
- Web page: https://patentgrep.com/patent/US11992640B2

## CPC

- A61M 37/00: Other apparatus for introducing media into the body (for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30); Percutany, i.e. introducing medicines into the body by diffusion through the skin (salt baths A61H33/04)
- A61F 7/007: {characterised by electric heating}
- A61K 33/38: Silver; Compounds thereof
- A61L 2/16: using chemical substances
- A61L 2/232: layered or coated
- A61M 35/003: {Portable hand-held applicators having means for dispensing or spreading integral media (hand-held massage devices with liquid delivery A61H7/003)}
- A61N 5/0625: {Warming the body, e.g. hyperthermia treatment}
- A61K 9/0009: {involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis}
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 9/06: Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)}
- A61K 47/02: Inorganic compounds
- A61L 2/04: Heat (radiation A61L2/08)
- A61L 2/084: Visible light
- A61L 2/085: Infrared radiation
- A61L 2/10: Ultraviolet [UV] radiation
- A61L 2103/05: Living organisms or biological materials
- A61L 2202/11: Apparatus for generating biocidal substances, e.g. vaporisers, UV lamps
- A61L 2202/14: Means for controlling sterilisation processes, data processing, presentation and storage means, e.g. sensors, controllers, programs
- A61L 2202/16: Mobile applications, e.g. portable devices, trailers, devices mounted on vehicles
- A61M 2037/0007: {having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents}
- A61M 2205/053: ultraviolet
- A61M 2205/3358: Measuring barometric pressure, e.g. for compensation
- A61M 2205/3368: Temperature
- A61M 2205/3561: local, e.g. within room or hospital
- A61M 2205/505: Touch-screens; Virtual keyboard or keypads; Virtual buttons; Soft keys; Mouse touches
- A61M 2205/583: by visual feedback
- A61M 2205/587: Lighting arrangements
- A61M 2205/8206: battery-operated
- A61N 5/0616: {Skin treatment other than tanning}
- A61N 5/0624: {for eliminating microbes, germs, bacteria on or in the body}
- A61N 2005/0651: {Diodes}
- A61N 2005/0667: {Filters}
- Y02A 50/30: Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)
- Y02A: TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE

## Abstract

A device comprising a housing having a handle end and a treatment end. The treatment end is configured to provide an antimicrobial treatment and a heat treatment. The treatment end comprises an applicator having an applicator surface for providing at least the heat treatment. The device includes a heat generation unit configured to heat the applicator surface in use, a source of antimicrobial agent, and a control unit operatively connected to at least the heat generation unit for controlling the heat generation unit. The device can be a hand-held device and used to apply topical treatment to a treatment area of a subject.

## Claims

### Claim 1

A method for inactivating a virus, the method comprising applying a heat treatment with an antimicrobial treatment comprising uncompounded silver or copper metal, such that the virus is inactivated by the release of metal ions from the uncompounded silver or copper metal caused by heat when the heat treatment is applied.

### Claim 2 (depends on 1)

The method of claim 1, wherein the heat treatment and the antimicrobial treatment is effected by applying a heated source of antimicrobial agents to an environment containing the virus.

### Claim 3 (depends on 1)

The method of claim 1, wherein the virus is Zika virus, West Nile virus, or Dengue virus.

### Claim 4 (depends on 1)

The method of claim 1, wherein the heat treatment comprises heating to a temperature of between 45-65° C., 50-60° C., 51-55° C. or about 51-54° C.

### Claim 5 (depends on 1)

The method of claim 1, wherein the heat treatment and/or the antimicrobial treatment is applied for about 3-15 seconds, about 10-15 seconds, about 5-35 seconds, about 10-35 seconds, about 20-35 seconds, or about 25-35 seconds.

### Claim 6 (depends on 1)

The method of claim 1, further comprising a light treatment.

### Claim 7 (depends on 6)

The method of claim 6, wherein the light treatment is within the ultraviolet, infrared or visible range of the electromagnetic spectrum.

### Claim 8

A method for treating a viral infection in a subject in need thereof, comprising topical application of a heat treatment with an antimicrobial treatment, comprising uncompounded silver or copper metal, to the subject, such that the viral infection is treated by the release of metal ions from the uncompounded silver or copper metal caused by heat when the heat treatment is applied.

### Claim 9 (depends on 8)

The method of claim 8, wherein a heated source of antimicrobial agents is applied topically to the subject.

### Claim 10 (depends on 8)

The method of claim 8, wherein the virus is Zika virus, West Nile virus, or Dengue virus.

### Claim 11 (depends on 9)

The method of claim 9, wherein the heated source of antimicrobial agents is heated to a temperature of between 45-65° C., 50-60° C., 51-55° C. or about 51-54° C.

### Claim 12 (depends on 8)

The method of claim 8, wherein the heat treatment and/or the antimicrobial treatment is applied for about 3-15 seconds, about 10-15 seconds, about 5-35 seconds, about 10-35 seconds, about 20-35 seconds, or about 25-35 seconds.

### Claim 13 (depends on 8)

The method of claim 8, further comprising application of a light treatment.

### Claim 14 (depends on 13)

The method of claim 13, wherein the light treatment is within the ultraviolet, infrared or visible range of the electromagnetic spectrum.

### Claim 15 (depends on 8)

The method of claim 8, further comprising application of at least one agent selected from an anti-inflammatory agent, an antibiotic agent, an antiviral agent, an antifungal agent, a skin soothing agent, a cooling agent, a heat-activatable agent, a wound healing agent, and a skin rejuvenating agent.

### Claim 16 (depends on 8)

The method of claim 8, wherein the heat treatment with the antimicrobial treatment is applied using a device comprising:
a housing having a handle end and a treatment end;
the treatment end being configured to provide an antimicrobial treatment comprising uncompounded silver or copper metal ions and a heat treatment, the treatment end comprising an applicator having an applicator surface for providing at least the heat treatment;
a heat generation unit configured to heat the applicator surface in use;
a source of antimicrobial agent; and
a control unit operatively connected to at least the heat generation unit for controlling the heat generation unit.