Devices and methods for delivering a substance to a body cavity

A device for delivering either one or more substances within at least one body cavity, comprises a base and a nosepiece;

• said nosepiece comprises:
• (i) at least one pierceable vial comprising Vsub [ml or mg] of said one or more substances;
• said at least one vial having at least one fluid inlet port of diameter Din [mm] and at least one fluid discharging outlet port of diameter Dout [mm], configured for placement in proximity to said at least one body cavity;
• (ii) a nosepiece cover configured by means of size and shape to cover at least partially said nosepiece;
• said base comprises:
• (i) at least one chamber configured to confine pressurized fluid at volume VPF [ml] and pressure PPF [barg];
• (ii) at least one puncturing member;
• said at least one fluid inlet port of said at least one vial configured by means of size and shape to interface with said at least one puncturing member;
• wherein actuation of said nosepiece cover configured to enable piercing of said at least one vial in said at least one fluid inlet port, by means of said at least one puncturing member;
• further wherein said volume VPF [ml] of said pressurized fluid at pressure PPF [barg] is configured to be released from said at least one chamber within a short period of time, <500 milliseconds (dT), via said at least one fluid inlet port, entrains said one or more substances, erupts via said at least one fluid discharging outlet port into said at least one body cavity, such that a release time of said Vsub [ml or mg] of said one or more substances and said VPF [ml] of said pressurized fluid, dTrelease is less than 500 milliseconds.

A method for delivering either one or more substances within at least one body cavity using a device, characterized by steps of

• a) providing at least one pierceable vial with Vsub [ml or mg] of said one or more substances;
• said at least one vial having at least one fluid inlet port of diameter Din [mm] and at least one fluid discharging outlet port of diameter Dout [mm], configured for placement in proximity to said at least one body cavity;
• b) configuring said at least one fluid inlet port by means of size and shape to interface a puncturing member, so that upon coupling to said at least one fluid inlet port, piercing of the at least one fluid inlet port, thereby providing said one or more substances in a fluid communication with at least one chamber configured to accept pressurized fluid at volume VPF [ml] and pressure PPF [barg];
• and
• c) facilitating the flow of said pressurized fluid from said at least one chamber, via said at least one fluid inlet port, entrains said one or more substances, erupts via said at least one fluid discharging outlet port into said at least one body cavity, such that a release time of said Vsub [ml or mg] of said one or more substances and said VPF [ml] of said pressurized fluid, dTrelease is less than 500 milliseconds;
• wherein
• i) VPF is in a range of 1 to 50 ml;
• ii) Vsub is in a range of about 0.01 to about 7 ml;
• iii) PPF is in a range of up to about 10 barg;
• further wherein at least one of the following is being held true
• iv) Din or Dout are in a range of 0.2 to 6 mm;
• v) a pressure velocity is greater than 0.001 barg/ms;
• vi) said pressure velocity is greater than 0.01 barg/ms;
• vii) a volume rate or dVsub/dTrelease is greater than 0.0001 ml/ms;
• viii) said volume rate dVsub/dTrelease is greater than 0.001 ml/ms;
• ix) a volume rate dVPF/dTrelease is greater than 0.001 ml/ms;
• x) said volume rate dVPF/dTrelease is greater than 0.01 ml/ms;
• and
• xi) any combination thereof;
• further wherein said step of providing said at least one vial additionally comprising step of selecting said at least one vial from a group consisting of a pierceable container, a blow-fill-seal and a form-fill-seal;
• wherein said device further comprises at least one plunger enclosed within said at least one chamber, said at least one plunger comprising at least one sealing member adapted to seal said at least one chamber and to prevent flow of said pressurized fluid;
• and
• wherein linear movement of said at least one plunger moves said at least one sealing member and creates a gap through which said pressurized fluid exits said at least one chamber.

A method for delivering either one or more substances within at least one body cavity, characterized by steps of:

• a) providing a device comprising:
• i) at least one pierceable vial comprising Vsub [ml or mg] of said one or more substances;
• said at least one vial having at least one fluid inlet port of diameter Din [mm] and at least one fluid discharging outlet port of diameter Dout [mm], configured for placement in proximity to said at least one body cavity;
• and
• ii) a nosepiece cover configured by means of size and shape to cover at least partially a nosepiece of the device;
• b) providing the device comprising:
• i) at least one chamber configured to confine pressurized fluid at volume VPF[ml] and pressure PPF [barg];
• and
• ii) at least one puncturing member;
• said at least one fluid inlet port of said at least one vial configured by means of size and shape to interface with said at least one puncturing member;
• c) actuating said device by piercing said at least one vial in said at least one fluid inlet port, by means of said at least one puncturing member;
• and
• d) releasing said volume VPF [ml] of said pressurized fluid at pressure PPF [barg] within a short period of time, <500 milliseconds (dT);
• out of said at least one chamber, via said at least one fluid inlet thereby entraining said one or more substances and erupting via said at least one fluid discharging outlet port into said at least one body cavity, such that a release time of said Vsub [ml or mg] of said one or more substances and said VPF [ml] of said pressurized fluid, dTrelease is less than 500 milliseconds.