# US 11,992,598 B2 · Adsorbing material for soluble tumor necrosis factor receptor

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- Number: US 11,992,598 B2
- Document ID: US11992598B2
- Status: Granted
- Kind: B2
- Application number: 17/442,247
- Filed: 2020-04-21
- Published: 2022-05-26
- Granted: 2024-05-28
- Earliest claimed: 2019-04-26
- Assignees: Toray Industries, Inc.
- Applicants: Toray Industries, Inc.
- Inventors: Kaoru Shimada; Megumi Nakanishi; Hiroshi Takahashi
- Web page: https://patentgrep.com/patent/US11992598B2

## CPC

- A61M 1/3679: {by absorption (A61M1/3675 takes precedence)}
- B01J 20/26: Synthetic macromolecular compounds
- B01J 20/28004: {Sorbent size or size distribution, e.g. particle size}
- B01J 20/28023: {Fibres or filaments (fibres or filaments in the form of membranes B01J20/28038; B01J20/28007 takes precedence)}
- B01J 20/28069: {Pore volume, e.g. total pore volume, mesopore volume, micropore volume}
- B01J 20/28078: {Pore diameter}
- B01J 20/321: {consisting of a polymer obtained by reactions involving only carbon to carbon unsaturated bonds}
- B01J 20/3219: {involving a particular spacer or linking group, e.g. for attaching an active group}
- B01J 20/3248: {the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such}
- B01J 20/327: {Polymers obtained by reactions involving only carbon to carbon unsaturated bonds}
- B01J 20/3272: {Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds}
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- B01J: CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS

## Abstract

The present invention aims to provide a material for adsorbing soluble tumor necrosis factor receptors with high efficiency. The present invention provides an adsorbing material for soluble tumor necrosis factor receptors, which includes a superficially porous water-insoluble polymeric material, wherein the pore size distribution curve for the surface of the water-insoluble polymeric material, which is derived from a distribution of melting points determined by differential scanning calorimeter, shows the peak radius in the range of 1 to 80 nm, and the water-insoluble polymeric material has a zeta potential at pH 7.4 of −15 to 15 mV, and the water-insoluble polymeric material is in fiber, particle, or film form.

## Claims

### Claim 1

An adsorbing material for soluble tumor necrosis factor receptors, comprising a superficially porous water-insoluble polymeric material,
wherein the pore size distribution curve for the surface of the water-insoluble polymeric material, which is derived from a distribution of melting points determined by differential scanning calorimeter, shows the peak radius in the range of 1 to 80 nm;
the water-insoluble polymeric material has a zeta potential at pH 7.4 of −15 to 15 mV; and
the water-insoluble polymeric material is in fiber, particle, or film form.

### Claim 2 (depends on 1)

The adsorbing material according to claim 1, wherein the water-insoluble polymeric material is in fiber form with a fiber diameter of 25 to 65 μm or in particle form with a particle size of 25 to 65 μm.

### Claim 3 (depends on 1)

The adsorbing material according to claim 1, wherein the ratio B defined by the following equation (1) is not less than 10% and not more than 90%, where A1 and A2 represent the areas of non-porous and porous regions, respectively, in a cross section passing through the center of the water-insoluble polymeric material and perpendicular to the longitudinal direction, and B represents the ratio of the area of the non-porous region:
B=A1/(A1+A2)×100 Equation (1).

### Claim 4 (depends on 1)

The adsorbing material according to claim 1, wherein the peak radius is in the range of 1 to 30 nm.

### Claim 5 (depends on 1)

The adsorbing material according to claim 1, wherein the water-insoluble polymeric material has a pore volume of 0.6 to 1.2 cm3/g.

### Claim 6 (depends on 1)

The adsorbing material according to claim 1, wherein an amino group-containing ligand is bound to the surface of the water-insoluble polymeric material.

### Claim 7 (depends on 1)

The adsorbing material according to claim 1, wherein the water-insoluble polymeric material contains polystyrene, polyethylene, or polypropylene as a main component.

### Claim 8 (depends on 1)

An adsorption column comprising the adsorbing material according to claim 1.