# US 11,992,597 B2 · Method and maintenance device for automatic maintenance of an autonomous dialysis system > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,992,597 B2 - Document ID: US11992597B2 - Status: Granted - Kind: B2 - Application number: 17/728,637 - Filed: 2022-04-25 - Published: 2022-11-10 - Granted: 2024-05-28 - Earliest claimed: 2021-05-07 - Assignees: Imec Vzw; Stichting IMEC Nederland - Applicants: Imec Vzw; Stichting IMEC Nederland - Inventors: Fokko Wieringa; Willem Van Roy; Patrick van Deursen; Lucas Lindeboom - Web page: https://patentgrep.com/patent/US11992597B2 ## CPC - A61M 1/3672: {Means preventing coagulation} - A61M 1/16: with membranes - A61M 1/1633: {with more than one dialyser unit} - A61M 1/1678: {intracorporal (peritoneal dialysis A61M1/28)} - A61M 1/361: {before treatment} - A61M 1/3612: {after treatment} - A61M 2205/3553: remote, e.g. between patient's home and doctor's office - A61M 2205/3584: using modem, internet or Bluetooth® - A61M 2205/70: with testing or calibration facilities - A61M 2205/707: Testing of filters for clogging - A61M 2205/7563: with means preventing clogging of filters - A61M 2205/7581: with means for switching over to a fresh filter on clogging or saturation - A61M 2209/088: on the body - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract According to an aspect there is provided a method for automatic maintenance of a dialysis system. The dialysis system includes a plurality of filter sections where each filter section includes a blood flow channel, a dialysate flow channel, and a membrane separating the blood flow channel from the dialysate flow channel and having a plurality of pores through which substances are exchanged between a blood flow in the blood flow channel and a dialysate flow in the dialysate flow channel. The method includes determining, for each filter section of the plurality of filter sections, whether a maintenance criterion is fulfilled. The method also includes triggering a maintenance event for a filter section of the plurality of filter sections for which the maintenance criterion is fulfilled. The method also includes executing the maintenance event and optionally administering a thrombolytic agent to the blood flow channel of the filter section. ## Claims ### Claim 1 A method for automatic maintenance of a dialysis system, wherein the dialysis system comprises a plurality of filter sections, wherein each filter section of the plurality of filter sections comprises a blood flow channel, a dialysate flow channel, and a membrane separating the blood flow channel from the dialysate flow channel and having a plurality of pores through which substances are exchanged between a blood flow in the blood flow channel and a dialysate flow in the dialysate flow channel, the method comprising: determining, for each individual filter section of the plurality of filter sections, whether a maintenance criterion is fulfilled; triggering a maintenance event for a filter section of the plurality of filter sections for which the maintenance criterion is fulfilled; and executing the maintenance event for the filter section, wherein said executing comprises: administering a thrombolytic agent to the blood flow channel of the filter section. ### Claim 2 (depends on 1) The method according to claim 1, wherein the determining whether a maintenance criterion is fulfilled comprises: determining whether a preventive maintenance criterion is fulfilled comprising determining whether a time duration since a nearest preceding maintenance event for the filter section is above a predetermined threshold. ### Claim 3 (depends on 1) The method according to claim 1, wherein the determining whether a maintenance criterion is fulfilled comprises: determining whether a corrective maintenance criterion is fulfilled comprising measuring, by at least one sensor per filter section, at least one parameter of the blood flow flowing through the blood flow channel of the filter section, prior to entry into the blood flow channel, inside the blood flow channel, and/or after exiting the blood flow channel, wherein the at least one parameter being any one from a blood flow rate, a blood flow pressure, a blood flow chemistry, a blood flow ion content, an electrical conductivity, an ultrasonic transmission or reflection parameter, and a presence of blood clots. ### Claim 4 (depends on 1) The method according to claim 1, wherein the executing the maintenance event for the filter section further comprises: switching, at a blood flow channel inlet, from a blood inlet to a thrombolytic agent inlet. ### Claim 5 (depends on 4) The method according to claim 4, further comprising: opening a blood flow channel inlet in a spare filter section, such that the number of filter sections operating with blood flow is constant, thereby maintaining full capacity of the dialysis system. ### Claim 6 (depends on 1) The method according to claim 1, wherein the executing the maintenance event for the filter section further comprises: receiving, at the inlet of the blood flow channel, the thrombolytic agent from a supply reservoir configured to store the thrombolytic agent. ### Claim 7 (depends on 1) The method according to claim 1, wherein the executing the maintenance event for the filter section further comprises: discarding, at an outlet of the blood flow channel, the thrombolytic agent to a waste reservoir configured to store waste thrombolytic agent. ### Claim 8 (depends on 1) The method according to claim 1, wherein the method further comprises: determining, upon finalizing the maintenance event for the filter section, whether the maintenance event was successful; upon the maintenance event not being successful, repeating the maintenance event up to a maximum number of attempts; determining, upon finalizing the maximum number attempts of maintenance events, whether the maintenance event was successful; classifying, upon the maintenance event not being successful and after reaching the maximum number of attempts, the filter section as irreparable; and connecting, upon the filter section being classified as irreparable, a spare filter section to the blood flow. ### Claim 9 (depends on 1) The method according to claim 1, wherein the method further comprises: sending a wireless message to an external unit, the wireless message including information about a status of the plurality of filter sections of the dialysis system. ### Claim 10 (depends on 1) The method according to claim 1, wherein the executing the maintenance event for the filter section further comprises: emitting, by one or more ultrasonic transducers, an ultrasonic signal into the blood flow channel, whereby the declotting effect of the applied thrombolytic agent is amplified.