# US 11,992,577 B2 · Adhesive for surgical staple line reinforcement

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- Number: US 11,992,577 B2
- Document ID: US11992577B2
- Status: Granted
- Kind: B2
- Application number: 17/443,470
- Filed: 2021-07-27
- Published: 2022-01-27
- Granted: 2024-05-28
- Earliest claimed: 2020-07-27
- Assignees: Cook Biotech Incorporated
- Applicants: Cook Biotech Incorporated
- Inventors: Loran Solorio; Steven Cohen; Benjamin Patrick Kline
- Web page: https://patentgrep.com/patent/US11992577B2

## CPC

- A61L 24/102: {Collagen}
- A61L 27/34: Macromolecular materials
- A61B 17/07292: {Reinforcements for staple line, e.g. pledgets}
- A61L 15/58: Adhesives
- A61L 24/001: {Use of materials characterised by their function or physical properties}
- A61L 24/08: Polysaccharides {(A61L24/043 takes precedence)}
- A61L 24/108: {Specific proteins or polypeptides not covered by groups A61L24/102 - A61L24/106}
- A61L 27/20: Polysaccharides
- A61L 27/3633: {Extracellular matrix [ECM]}
- C08L 1/286: {substituted with acid radicals, e.g. carboxymethyl cellulose [CMC] (C08L1/282 takes precedence)}
- C08L 5/08: Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
- A61B 2017/00951: {adhesive}
- A61L 2300/414: Growth factors
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- C08L: COMPOSITIONS OF MACROMOLECULAR COMPOUNDS (compositions based on polymerisable monomers C08F, C08G; artificial filaments or fibres D01F; textile treating compositions D06)

## Abstract

The present disclosure provides medical products including an adhesive containing a carboxyalkyl cellulose and sorbitol. Such medical products can find use as a bolster material for use in conjunction with a surgical fastening device such as a stapler. Such adhesives may include advantageous properties such as the ability to retain tack while stored under a peelable cover. Related methods of manufacture and use are also described.

## Claims

### Claim 1

A medical product, comprising:
a medical graft material; and
an adhesive on at least a portion of a surface of said medical graft material, wherein said adhesive comprises: chondroitin sulfate, carboxymethyl cellulose, sorbitol, and maltitol.

### Claim 2 (depends on 1)

The medical product of claim 1, wherein said carboxyalkyl cellulose is carboxymethyl cellulose, and wherein said carboxymethyl cellulose and said chondroitin sulfate are present in a dry weight ratio of 10:1 to 1:3.

### Claim 3 (depends on 1)

The medical product of claim 1, wherein said sorbitol and said maltitol are present in a dry weight ratio of 10:1 to 1:1.

### Claim 4 (depends on 1)

The medical product of claim 1, wherein said adhesive further comprises sodium chloride, and wherein said sorbitol and said sodium chloride are present in a dry weight ratio of 10:1 to 1:1.

### Claim 5 (depends on 1)

The medical product of claim 1, wherein said medical graft material is contained within an inner space of a sterile package, and wherein said sterile package is configured to maintain the inner space at a humidity level of 50-65% relative humidity.

### Claim 6

A medical adhesive comprising:
a carboxyalkyl cellulose, sorbitol, maltitol, a sulfated glycosaminoglycan, and a salt.

### Claim 7 (depends on 6)

The medical adhesive of claim 6, wherein said sorbitol and said maltitol are present in a dry weight ratio of 10:1 to 1:1.

### Claim 8 (depends on 6)

The medical adhesive of claim 6, wherein said a carboxyalkyl cellulose comprises carboxymethyl cellulose, said sulfated glycosaminoglycan comprises chondroitin sulfate, and said salt comprises sodium chloride, and wherein said chondroitin sulfate, said carboxymethyl cellulose, said sorbitol, said maltitol, and said sodium chloride are present in a dry weight ratio of 1:1:10:3:1.7.

### Claim 9 (depends on 6)

The medical adhesive of claim 6, wherein said adhesive has a moisture content of 5% to 15%.

### Claim 10

A medical adhesive comprising:
a carboxyalkyl cellulose, a sugar alcohol, and at least one of a sulfated glycosaminoglycan and a crystallization inhibiting salt.

### Claim 11 (depends on 10)

The medical adhesive of claim 10, wherein said carboxyalkyl cellulose comprises carboxymethyl cellulose, wherein said sulfated glycosaminoglycan comprises chondroitin sulfate, and wherein said carboxymethyl cellulose and said chondroitin sulfate are present in a dry weight ratio of 10:1 to 1:3.

### Claim 12 (depends on 10)

The medical adhesive of claim 10, comprising sorbitol and maltitol in a dry weight ratio of 10:1 to 1:1.

### Claim 13 (depends on 10)

The medical adhesive of claim 10, wherein said crystallization inhibiting salt comprises sodium chloride, and said sugar alcohol comprises sorbitol, and wherein said sorbitol and said sodium chloride are present in the adhesive in a dry weight ratio of 10:1 to 1:1.

### Claim 14 (depends on 13)

The medical adhesive of claim 13, comprising sorbitol and said sodium chloride in a dry weight ratio of 10:1 to 1:1.