# US 11,992,575 B2 · Radioactive liquid embolic

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- Number: US 11,992,575 B2
- Document ID: US11992575B2
- Status: Granted
- Kind: B2
- Application number: 16/750,635
- Filed: 2020-01-23
- Published: 2020-08-06
- Granted: 2024-05-28
- Earliest claimed: 2017-10-09
- Assignees: MicroVention, Inc.
- Applicants: MicroVention, Inc.
- Inventors: Gregory M. Cruise; Xinping Wu; Matthew J. Fitz; Yue Wu
- Web page: https://patentgrep.com/patent/US11992575B2

## CPC

- A61L 24/0005: {Ingredients of undetermined constitution or reaction products thereof}
- A61L 24/001: {Use of materials characterised by their function or physical properties}
- A61L 24/0015: {Medicaments; Biocides}
- A61L 2300/428: Vitamins, e.g. tocopherol, riboflavin
- A61L 2300/44: Radioisotopes, radionuclides
- A61L 2400/12: Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
- A61L 2430/36: for embolization or occlusion, e.g. vaso-occlusive compositions or devices
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)

## Abstract

Liquid embolic preparations and medical treatment methods of using those preparations are described. In some embodiments, the preparations or solutions can transition from a liquid to a solid for use in the embolization. The preparations can include biocompatible polymers with covalently bound radioactive iodine isotopes.

## Claims

### Claim 1

A polymeric composition, comprising a non-physiological solution, and a folate-polymer conjugate that is a reaction product of:
1) A biocompatible polymer comprising a reaction product of:
a first monomer including a polymerizable moiety having a biodegradable linkage to a visualization agent having at least one aromatic ring, wherein the at least one aromatic ring includes at least one iodine atom, wherein at least one of the at least one iodine atom is a radioactive isotope,
and a second monomer comprising hydroxyethyl methacrylate; and
2) A folate compound having the formula:
wherein n is 0-100;
wherein the folate compound is conjugated to the hydroxy moiety of the hydroxyethyl methacrylate;
wherein the folate-polymer conjugate is soluble in the non-physiological solution and insoluble in a physiological solution; and
wherein the folate-polymer conjugate comprises the formula:
wherein n is 0-100.

### Claim 2 (depends on 1)

The polymeric composition of claim 1, wherein the biodegradable linkage is SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO: 10, SEQ ID NO: 11, or SEQ ID NO: 12.

### Claim 3 (depends on 1)

The polymeric composition of claim 1, wherein n is 1, 2, 3, 4, 5, 6, or 100.

### Claim 4 (depends on 1)

The polymeric composition of claim 1, wherein the radioactive isotope is 123I, 124I, 125I, 131I, or a combination thereof.

### Claim 5 (depends on 1)

The polymeric composition of claim 1, wherein the radioactive isotope is 123I.

### Claim 6 (depends on 1)

The polymeric composition of claim 1, wherein the radioactive isotope is 124I.

### Claim 7 (depends on 1)

The polymeric composition of claim 1, wherein the radioactive isotope is 125I.

### Claim 8 (depends on 1)

The polymeric composition of claim 1, wherein the radioactive isotope is 131I.

### Claim 9 (depends on 1)

The polymeric composition of claim 1, wherein the first monomer is functionalized triiodophenol, 1-((2-(methacryloyloxy)ethoxy)carbonyloxy)ethyl-3,5-diacetamido-2,4,6-triiodobenzoate, 2-oxo-2-(1-oxo-1-(1-oxo-1-(2,4,6-triiodophenoxy)propan-2-yloxy)propan-2-yloxy)ethoxy)ethyl acrylate, or a combination thereof.

### Claim 10 (depends on 1)

The polymeric composition of claim 1, wherein n is 1.

### Claim 11

A polymeric composition, comprising a non-physiological solution and a folate-polymer conjugate, wherein:
the folate-polymer conjugate comprises a visualization agent having at least one aromatic ring, wherein the at least one aromatic ring includes at least one iodine atom, wherein at least one of the at least one iodine atom is a radioactive isotope,
the folate-polymer conjugate comprises the formula:
wherein n is 0-100; and
the folate-polymer conjugate is soluble in the non-physiological solution and insoluble in a physiological solution.

### Claim 12 (depends on 11)

The polymeric composition of claim 11, wherein n is 1, 2, 3, 4, 5, 6, or 100.

### Claim 13 (depends on 11)

The polymeric composition of claim 11, wherein n is 1.