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US 11,992,535 B2Granted
Compounds and probes for imaging huntingtin protein
AssigneeCHDI Foundation, Inc.
InventorsLongbin Liu, Matthew Lee, Celia Dominguez, Peter David Johnson, Christopher John Brown, Sarah Hayes, Adrian Kotey, Matthew Robert Mills, Michael Edward Prime
Life of this patent
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Abstract
Provided herein are certain compounds and imaging agents useful for detecting a condition or disorder associated with protein aggregation, compositions thereof, and methods of their use.
Claims39
A compound of Formula (I):
- or an isotopically labeled analog, pharmaceutically acceptable salt, solvate, stereoisomer, or mixture of stereoisomers thereof,
- wherein:
- Z1 and Z2 are each independently CH, or one of Z1 and Z2 is N and the other is CH;
- Z3 is N or CH;
- L1 is —O—C1-4 alkylene;
- one of X1 and X2 is N-L2-R2 and the other is CH2;
- X3 is CH2 or —O—CH2—;
- L2 is —C(═O)—;
- R1 is heteroaryl optionally substituted with one or two substituents independently selected from hydroxy, alkyl, alkoxy, haloalkoxy, and —N(R4)2;
- R2 is aryl, heteroaryl, heterocycloalkyl, or heterocycloalkenyl, each of which is substituted with one or two substituents independently selected from halogen, haloalkyl, hydroxy, alkyl, alkoxy, haloalkoxy, heteroaryl, and —N(R4)2;
- wherein when R2 is substituted with alkyl, the alkyl is optionally substituted with alkenyl or alkoxy;
- wherein when R2 is substituted with alkoxy, the alkoxy is optionally substituted with alkenyl or alkoxy;
- p is 0, 1, or 2;
- each R3 is independently C1-4 alkyl;
- and
- each R4 is independently H or C1-4alkyl.
13 more elements
A compound selected from
- Example
- Structure
- 1
- 1.1
- 1.2
- 1.3
- 1.4
- 1.5
- 1.6
- 1.8
- 1.10
- 1.11
- 1.12
- 1.13
- 1.14
- 1.15
- 1.16
- 1.17
- 1.18
- 1.19
- 1.20
- 1.21
- 1.22
- 1.23
- 1.24
- 1.25
- 1.26
- 1.27
- 1.28
- 1.29
- 4.3
- 9
- 15
- 16
- 20
- 24
- 24.1
- 24.2
- 24.3
- 24.4
- 25
- 26
- 28
- 31
- 34
- 34.1
- 35
- 35.1
- 36
- 37
- 38
- 40
- 41
- or an isotopically labeled analog, pharmaceutically acceptable salt, solvate, stereoisomer, or mixture of stereoisomers thereof.
51 more elements
Dependencies are inferred from the claim text.