Molecular vaccines for infectious disease
AssigneeAgilent Technologies, Inc.
InventorsJørgen Schøller, Henrik Pedersen, Liselotte Brix
Life of this patent
Estimating the term…
Abstract
The present invention relates to methods for construction of pharmamers i.e. vaccine components characterized by their multimerization domain and the attached biologically active molecules, and their use in preparation of vaccines that contains the pharmamers alone or in combination with other molecules. The individual molecules of the construct can be bound to each other or the multimerization domain(s) by covalent or non-covalent bonds, directly or via linkers. The invention further relates to the use of such preparations in vaccine settings aimed to function as preventive/prophylactic or therapeutic vaccines in humans and animals.
Claims35
A composition comprising one or more pharmamers, each pharmamer comprising two or more biologically active molecules attached to one or more multimerization domains, wherein the two or more biologically active molecules comprise two or more cytokines selected from the group consisting of IL-1, IL-2, IL-3, IL-4, IL-6, IL-7, IL-8, IL-10, IL-11, IL-12, IL-15, IL-16, IL-17, IL-18, IL-19, IL-20, IL-21, IL-22, IL-23, IL-24, IL-25, IL-26, IL-27, IL-28, -IL-29, IL-30, IL-31, IL-32, IL-33, IL-34 and IL-35, wherein one of said two or more cytokines is IL-21 and another is either IL-2 or IL-15, and wherein the one or more multimerization domains comprise a dextran molecule.
A pharmamer comprising
- (i) two or more biologically active molecules, wherein the two or more biologically active molecules comprise two or more cytokines selected from the group consisting of IL-1, IL-2, IL-3, IL-4, IL-6, IL-7, IL-8, IL-10, IL-11, IL-12, IL-15, IL-16, IL-17, IL-18, IL-19, IL-20, IL-21, IL-22, IL-23, IL-24, IL-25, IL-26, IL-27, IL-28, -IL-29, IL-30, IL-31, IL-32, IL-33, IL-34 and IL-35, and
- (ii) one or more multimerization domains comprising a dextran molecule, wherein the two or more biologically active molecules are attached to the one or more multimerization domains, and
- wherein one of said two or more cytokines is IL-21, and another is either IL-2 or IL-15.
Dependencies are inferred from the claim text.