# US 11,992,497 B2 · Cannabinoid derivatives and their use

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- Number: US 11,992,497 B2
- Document ID: US11992497B2
- Status: Granted
- Kind: B2
- Application number: 18/299,511
- Filed: 2023-04-12
- Published: 2023-10-12
- Granted: 2024-05-28
- Earliest claimed: 2021-08-04
- Assignees: Demeetra Agbio, Inc.
- Applicants: Demeetra AgBio, Inc.
- Inventors: John Crawford; Christopher Chengelis
- Web page: https://patentgrep.com/patent/US11992497B2

## CPC

- A61K 31/658: {o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol}
- A61K 9/0053: {Mouth and digestive tract, i.e. intraoral and peroral administration}
- A61K 31/05: Phenols {(cannabinoids A61K31/658)}
- A61K 31/085: having an ether linkage to aromatic ring nuclear carbon
- A61K 31/09: having two or more such linkages
- A61P 1/00: Drugs for disorders of the alimentary tract or the digestive system
- A61P 1/04: for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 35/00: Antineoplastic agents
- C07C 39/19: containing carbon-to-carbon double bonds but no carbon-to-carbon triple bonds
- C07C 43/215: having unsaturation outside the six-membered aromatic rings
- C07C 43/23: containing hydroxy or O-metal groups
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS

## Abstract

Provided herein are methods of using a compound of Formula (I) or pharmaceutically acceptable salt thereof, for example, in the treatment of a mental health disorder or chronic inflammatory disease.

## Claims

### Claim 1

A compound having the structure:

### Claim 2 (depends on 1)

A pharmaceutical composition comprising the compound of claim 1, and a pharmaceutically acceptable carrier.

### Claim 3 (depends on 1)

A method of treating a chronic inflammatory disease in a subject in need thereof, the method comprising administering to the subject the compound of claim 1, wherein the chronic inflammatory disease is an inflammatory bowel disease.

### Claim 4 (depends on 3)

The method of claim 3 wherein the inflammatory disease is Crohn's disease.

### Claim 5 (depends on 3)

The method of claim 3, wherein the inflammatory disease is ulcerative colitis.

### Claim 6 (depends on 3)

The method of claim 3, wherein the compound is administered orally.

### Claim 7 (depends on 1)

A method of treating epilepsy in a subject in need thereof, the method comprising administering to the subject the compound of claim 1.

### Claim 8 (depends on 1)

A method of treating seizure in a subject in need thereof, the method comprising administering to the subject the compound of claim 1.