# US 11,992,492 B2 · Composition for preventing or treating cellular senescence-associated diseases, containing homoharringtonine as active ingredient

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- Number: US 11,992,492 B2
- Document ID: US11992492B2
- Status: Granted
- Kind: B2
- Application number: 17/413,101
- Filed: 2019-10-11
- Published: 2022-01-27
- Granted: 2024-05-28
- Earliest claimed: 2018-12-13
- Assignees: Research Cooperation Foundation of Yeungnam University
- Applicants: Research Cooperation Foundation of Yeungnam University
- Inventors: Jae-Ryong Kim; Eok-Cheon Kim; Kyong-Jin Jung; Bum-Ho Bin; You Lim Son
- Web page: https://patentgrep.com/patent/US11992492B2

## CPC

- A61K 31/55: having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K 8/49: containing heterocyclic compounds
- A61P 9/10: for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A61P 13/12: of the kidneys
- A61P 19/00: Drugs for skeletal disorders
- A61P 27/02: Ophthalmic agents
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 39/06: Free radical scavengers or antioxidants
- A61Q 19/02: for chemically bleaching or whitening the skin
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

The present invention relates to a composition for preventing or treating cellular senescence-associated diseases comprising homoharringtonine as an active ingredient, and it was confirmed that the composition comprising homoharringtonine as an active ingredient exhibits a senolytics effect of selectively killing aging-induced fibroblasts and renal tubular cells, whereas aging-induced vascular endothelial cells and epithelial melanocytes and retinal pigmented epithelial cells, and exhibits a senomorphics effect of restoring the function and morphology of cells, and thus the homoharringtonine acts differently depending on the type of cells to effectively prevent or treat senile eye disease, tissue fibrosis disease, atherosclerosis, osteoarthritis, degenerative brain disease, chronic skin damage, obesity and diabetes caused by cellular aging and can be provided as a composition for whitening skin and life extension.

## Claims

### Claim 1

A method of treating a renal cell cancer and a renal fibrosis comprising administering a pharmaceutical composition comprising homoharringtonine as an active ingredient to a subject in need of the treating the renal cell cancer and the renal fibrosis,
wherein the renal cell cancer and the renal fibrosis are induced by a renal ischemia-reperfusion injury.

### Claim 2 (depends on 1)

The method of claim 1, wherein the homoharringtonine selectively kills a senescent cell or restores function or morphology of the senescent cell to a normal cell to treat the renal cell cancer and the renal fibrosis.

### Claim 3

A method of treating peritoneal fibrosis comprising administering a pharmaceutical composition comprising homoharringtonine as an active ingredient to a subject in need of the treating the peritoneal fibrosis,
wherein the peritoneal fibrosis is induced by chlorhexidine gluconate.

### Claim 4 (depends on 3)

The method of claim 3, wherein the homoharringtonine selectively kills a senescent cell or restores function or morphology of the senescent cell to a normal cell to treat the peritoneal fibrosis.