# US 11,992,471 B2 · Reelin/VEGF-C production/activation promoter and skin external composition using the same

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- Number: US 11,992,471 B2
- Document ID: US11992471B2
- Status: Granted
- Kind: B2
- Application number: 18/059,332
- Filed: 2022-11-28
- Published: 2023-06-01
- Granted: 2024-05-28
- Earliest claimed: 2021-11-29
- Assignees: Amorepacific Corporation
- Applicants: Amorepacific Corporation
- Inventors: Phil June Park; Hyunsoo Kim; Hyoung June Kim
- Web page: https://patentgrep.com/patent/US11992471B2

## CPC

- A61K 31/13: Amines {(A61K31/04 takes precedence)}
- A61K 31/185: Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids (hydroxamic acids A61K31/16; peroxy acids A61K31/327)
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 47/02: Inorganic compounds
- A61K 47/12: Carboxylic acids; Salts or anhydrides thereof
- A61K 47/36: Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K 47/46: Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
- A61P 9/00: Drugs for disorders of the cardiovascular system
- A61P 17/00: Drugs for dermatological disorders
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Provided are a reelin and/or VEGF-C production and/or VEGF-C activation promoter including a compound including a sulfonic acid group and an amino group as an active ingredient, and a skin external composition including the compound.

## Claims

### Claim 1

A method for improving swelling, lymphedema, skin wrinkles, or obesity by applying an effective amount of the reelin and/or VEGF-C production and/or activation promoter comprising a compound of the following Chemical Formula 1 to skin of a subject:
wherein, in Chemical Formula 1,
L1 is a substituted or unsubstituted C1 to C20 alkylene group or a substituted or unsubstituted C6 to C20 arylene group.

### Claim 2 (depends on 1)

The method of claim 1, wherein
L1 is an unsubstituted C1 to C10 alkylene group.