# US 11,992,467 B2 · Promotion of lymphatic function

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- Number: US 11,992,467 B2
- Document ID: US11992467B2
- Status: Granted
- Kind: B2
- Application number: 17/652,432
- Filed: 2022-02-24
- Published: 2022-06-09
- Granted: 2024-05-28
- Earliest claimed: 2014-11-18
- Assignees: Universitaet Basel; Eth Zuerich
- Applicants: Universitaet Basel; Eth Zuerich
- Inventors: Michael Detmar; Matthias Hamburger; Olivier Potterat; Adriana Sliwa-Primorac
- Web page: https://patentgrep.com/patent/US11992467B2

## CPC

- A61K 31/11: Aldehydes
- A61K 8/34: Alcohols
- A61K 8/345: {containing more than one hydroxy group}
- A61K 36/88: Liliopsida (monocotyledons)
- A61Q 19/00: Preparations for care of the skin
- A61K 2236/333: using mixed solvents, e.g. 70% EtOH
- A61K 2800/10: General cosmetic use
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

The present invention refers to lipophilic extracts of members of the Iridaceae family, such as Iris germanica and/or Iris pallida, that have been found to promote lymphatic function. These extracts are suitable for the treatment of skin inflammation, rheumatoid arthritis, impaired wound healing, chronic inflammatory diseases, chronic airway inflammation, inflammatory bowel disease, rosacea, primary and/or secondary lymphedemas. The most active components were found to be the iridals.

## Claims

### Claim 1

A method for treating a disease related to impaired lymphatic function comprising administering to a subject in need thereof a lipophilic extract of a member of the Iridaceae family selected from the group consisting of Iris germanica, Iris pallida, and mixtures thereof, wherein the disease is selected from the group consisting of primary lymphedemas, and secondary lymphedemas.

### Claim 2 (depends on 1)

The method of claim 1, wherein said lipophilic extract is a lipophilic extract of the rhizome of the member of the Iridaceae family.

### Claim 3 (depends on 1)

The method of claim 1, wherein said lipophilic extract is a lipophilic extract of Iris germanica.

### Claim 4 (depends on 3)

The method of claim 3, wherein said lipophilic extract is a lipophilic extract of the rhizome of Iris germanica.

### Claim 5

A method for treating a disease related to impaired lymphatic function comprising administering to a subject in need thereof one or more iridals, wherein said disease is selected from the group consisting of primary lymphedemas, and secondary lymphedemas.

### Claim 6 (depends on 5)

The method of claim 5, wherein said one or more iridals are selected from the group consisting of iripallidal, iriflorental, γ-irigermanal, α-irigermanal, the cis isomer of α-irigermanal, the cis isomer of α-dehydroirigermanal, and mixtures thereof.

### Claim 7 (depends on 6)

The method of claim 6, wherein said one or more iridals comprises iripallidal.