# US 11,992,439 B2 · System for therapy of the eye by treating tissue using non-linear interaction > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,992,439 B2 - Document ID: US11992439B2 - Status: Granted - Kind: B2 - Application number: 17/226,890 - Filed: 2021-04-09 - Published: 2021-08-26 - Granted: 2024-05-28 - Earliest claimed: 2016-07-18 - Assignees: Carl Zeiss Meditec AG - Applicants: Carl Zeiss Meditec AG - Inventors: Thomas Nobis; Marco Hanft; Mark Bischoff - Web page: https://patentgrep.com/patent/US11992439B2 ## CPC - A61F 9/008: using laser - A61B 3/10: Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions - A61F 9/00825: {for photodisruption} - A61F 2009/0087: {Lens} - A61F 2009/00872: {Cornea} - A61F 2009/00887: {Cataract} - A61F 2009/00889: {Capsulotomy} - A61F 2009/00897: {Scanning mechanisms or algorithms} - A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract A system for therapy of the eye by treating tissue with therapeutic radiation using nonlinear interaction. A laser device is provided, which delivers the therapeutic radiation. The therapeutic radiation is focussed by a focussing device in an image field, and xy scanners and z scanners shift the focus laterally and longitudinally within a treatment volume. The therapeutic radiation is either a second short pulse radiation or a first short pulse radiation, each of which have a spectral centroid within a wavelength range defined by the short pulse properties. The system is particularly corrected with regard to longitudinal chromatic aberrations and lateral chromatic aberrations such that the spectral characteristic curves of the two aberrations each have a local extreme within the wavelength ranges, and a certain tolerance within the wavelength ranges is not exceeded, therefore the characteristic curves are very shallow. ## Claims ### Claim 1 A system for therapy or measurement of the eye by treating tissue using nonlinear interaction with therapy or measurement radiation, the system comprising: a laser device for providing the therapy or measurement radiation in a form of a first short-pulse radiation at a first centroid wavelength and of a second short-pulse radiation at a second centroid wavelength, which differs from the first centroid wavelength by at least 300 nm, wherein due to a pulse length of the first radiation, the first radiation covers a first wavelength range about the first centroid wavelength, and due to a pulse length of the second radiation, the second radiation covers a second wavelength range about the second centroid wavelength, a focusing device, including an objective lens, which comprises an image field lying in a therapy or measurement volume and which focuses the therapy or measurement radiation onto a focus in the image field such that the treatment or measurement is producible within the tissue using the nonlinear interaction, a z-scanner device, including a moveable lens, which adjusts a depth position of the focus in the therapy or measurement volume, and a control device for controlling the z-scanner device, wherein the system is configured to operate with the first radiation or the second radiation, but not simultaneously with both the first radiation and the second radiation, wherein optics of the system, including the objective lens of the focusing device, and the moveable lens of the z-scanner device, are configured to produce: a first longitudinal chromatic aberration which is constant over the first wavelength range within a first predetermined longitudinal chromatic aberration tolerance, and a second longitudinal chromatic aberration which is constant over the second wavelength range within a second predetermined longitudinal chromatic aberration tolerance, wherein the first and second longitudinal chromatic aberrations are different from each other causing a depth position offset of the focus of the second radiation against the focus of the first radiation and, wherein the control device is configured to control the z-scanner device such that, during operation with the second short-pulse radiation, the depth position offset is compensated by adjusting a position of the moveable lens of the z-scanner device. ### Claim 2 (depends on 1) The system as claimed in claim 1, further comprising an xy-scanner device for lateral displacement of the focus in the image field, wherein the optics of the system, including the objective lens of the focusing device, and the moveable lens of the z-scanner device, are further configured to produce a non-zero transverse chromatic aberration at at least one of the two centroid wavelengths, the non-zero transverse chromatic aberration being constant over the respective wavelength range around the at least one of the two centroid wavelengths within a predetermined transverse chromatic aberration tolerance, and wherein the control device is further configured to control the xy-scanner device such that the transverse chromatic aberration is compensated for in the lateral displacement of the focus. ### Claim 3 (depends on 1) The system as claimed in claim 1, wherein one of the two centroid wavelengths is not greater than 420 nm, and the other of the two centroid wavelengths is not less than 730 nm. ### Claim 4 (depends on 1) The system as claimed in claim 1, wherein one of the two centroid wavelengths is between 380 and 420 nm and the other of the two wavelengths is between 1030 nm and 1060 nm. ### Claim 5 (depends on 1) The system as claimed in claim 1, wherein the two wavelength ranges are each not wider than 30 nm in particular not wider than 15 nm. ### Claim 6 (depends on 1) The system as claimed in claim 1, wherein a z-travel of the focus of the z-scanner device is at least 1 mm, in particular at least 13 mm. ### Claim 7 (depends on 1) The system as claimed in claim 1, comprising an optical correction element, which only acts on the second short-pulse radiation or which is only activated during operation with the second short-pulse radiation, said optical correction element making the second longitudinal chromatic aberration to be constant over the second wavelength range within the second predetermined longitudinal chromatic aberration tolerance. ### Claim 8 (depends on 1) The system as claimed in claim 1, further comprising an optical correction element which is located in a beam path section selectively guiding the first or the second radiation, said optical correction element being activable to produce a corrective effect making the second longitudinal chromatic aberration to be constant over the second wavelength range within the second predetermined longitudinal chromatic aberration tolerance, wherein the control device is further configured to activate the optical correction element to produce the corrective effect when the second radiation passes through the system, and to deactivate the correction lens to cease the corrective effect when the first radiation passes through the system. ### Claim 9 A system for therapy or measurement of the eye by treating tissue using nonlinear interaction with therapy or measurement radiation, the system comprising: a laser device for providing the therapy or measurement radiation in a form of a first short-pulse radiation at a first centroid wavelength and of a second short-pulse radiation at a second centroid wavelength, which differs from the first centroid wavelength by at least 300 nm, wherein due to a pulse length of the first radiation, the first radiation covers a first wavelength range about the first centroid wavelength and due to a pulse length of the second radiation, the second radiation covers a second wavelength range about the second centroid wavelength, a focusing device, including an objective lens, which comprises an image field lying in a therapy or measurement volume and which focuses the therapy or measurement radiation onto a focus in the image field such that the treatment or measurement is producible within the tissue using the nonlinear interaction, and a z-scanner device, including a moveable lens, which adjusts a depth position of the focus in the therapy or measurement volume, wherein the system is configured to operate with the first radiation or the second radiation, but not simultaneously with both the first radiation and the second radiation, wherein optics of the system, including the objective lens of the focusing device, and the moveable lens of the z-scanner device, are configured to produce: a first longitudinal chromatic aberration which is constant over the first wavelength range within a first predetermined longitudinal chromatic aberration tolerance, and a second longitudinal chromatic aberration which is constant over the second wavelength range within a second predetermined longitudinal chromatic aberration tolerance wherein the first and second longitudinal chromatic aberrations are different from each other causing a depth position offset of the focus of the second radiation against the focus of the first radiation, and wherein the system comprises an optical refocusing element, which acts on the second radiation during operation with the second radiation, said refocusing element compensating the depth position offset. ### Claim 10 (depends on 9) The system as claimed in claim 9, wherein the optical refocusing element is provided in a beam path section guiding only the second radiation. ### Claim 11 (depends on 9) The system as claimed in claim 9, comprising a first input beam path for the first radiation and a second input beam path for the second radiation and a beam combiner disposed upstream of the focusing device, said beam combiner merging the two input beam paths or switching between the two input beam paths, wherein the optical refocusing element is located only in the second input beam path but not in the first input beam path. ### Claim 12 (depends on 9) The system as claimed in claim 9, wherein the optical refocusing element comprises a drive for activating the refocusing element to perform depth position offset compensation, the system further comprising a control device for controlling the drive to activate the refocusing element only if the second radiation passes through the system. ### Claim 13 (depends on 9) The system as claimed in claim 9, wherein the optical refocusing element is located in a pupil of the objective lens and comprises an adjustable optical element, the system further comprising a control device for controlling the adjustable optical element to depth position offset compensate only if the system operates with the second short-pulse radiation. ### Claim 14 (depends on 9) The system as claimed in claim 9, wherein the adjustable optical element comprises at least one of: a switchable lens, a pivotable lens, a varifocal lens and a microelectromechanical system (MEMS) array. ### Claim 15 (depends on 9) The system as claimed in claim 9, further comprising an optical correction element which is located in a beam path section selectively guiding the first or the second radiation, said optical correction element being activatable to produce a corrective effect making the second longitudinal chromatic aberration to be constant over the second wavelength range within the second predetermined longitudinal chromatic aberration tolerance, and a control device for activating the optical correction element to produce the corrective effect when the second radiation passes through the system, and for deactivating the optical correction element to cease the corrective effect when the first radiation passes through the system. ### Claim 16 (depends on 15) The system as claimed in claim 15, wherein the optical refocusing element includes the optical correction element. ### Claim 17 (depends on 9) The system as claimed in claim 9, further comprising an xy-scanner device for lateral displacement of the focus in the image field, wherein the optics of the system, including the objective lens of the focusing device, and the moveable lens of the z-scanner device, are further configured to produce a non-zero transverse chromatic aberration at at least one of the two centroid wavelengths, the non-zero transverse chromatic aberration being constant over the respective wavelength range around the at least one of the two centroid wavelengths within a predetermined transverse chromatic aberration tolerance, and wherein the control device is further configured to control the xy-scanner device such that the transverse chromatic aberration is compensated for in the lateral displacement of the focus. ### Claim 18 (depends on 9) The system as claimed in claim 9, wherein one of the two centroid wavelengths is not greater than 420 nm, and the other of the two centroid wavelengths is not less than 730 nm. ### Claim 19 (depends on 9) The system as claimed in claim 9, wherein one of the two centroid wavelengths is between 380 and 420 nm and the other of the two wavelengths is between 1030 nm and 1060 nm. ### Claim 20 (depends on 9) The system as claimed in claim 9, wherein the two wavelength ranges are each not wider than 30 nm, in particular not wider than 15 nm.