# US 11,992,425 B2 · Spring loaded medical device > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,992,425 B2 - Document ID: US11992425B2 - Status: Granted - Kind: B2 - Application number: 16/832,300 - Filed: 2020-03-27 - Published: 2020-11-12 - Granted: 2024-05-28 - Earliest claimed: 2019-03-29 - Assignees: Picosun Oy - Applicants: Picosun Oy - Inventors: Marko Pudas; Niku Oksala - Web page: https://patentgrep.com/patent/US11992425B2 ## CPC - A61F 2/82: Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents (stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07) - A61L 31/088: {Other specific inorganic materials not covered by A61L31/084 or A61L31/086} - A61L 31/10: Macromolecular materials - A61L 31/148: {Materials at least partially resorbable by the body} - A61F 2210/0004: bioabsorbable - A61F 2220/005: using adhesives - A61F 2240/001: Designing or manufacturing processes - A61F 2250/0031: made from both resorbable and non-resorbable prosthetic parts, e.g. adjacent parts - A61F 2250/0067: Means for introducing or releasing pharmaceutical products into the body - A61L 2400/12: Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces - A61L 2420/02: Methods for coating medical devices - A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C) - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) ## Abstract A structure is provided comprising a number of surfaces 10, 20 joined together with an adhesive 30, said structure being configured to reshape upon at least partial degradation of the adhesive 30. Related method and uses are further provided. ## Claims ### Claim 1 A structure, comprising: a plurality of surfaces; and an adhesive layer, as an Atomic Layer Deposition (ALD) coating layer of thickness 0.1-100 nm on all surfaces of the structure, wherein the plurality of surfaces are joined together by the adhesive layer in a first configuration having a collapsed shape, wherein the structure in the first configuration bears a mechanical load resulting from the adhesive layer joining said plurality of surfaces together and forming the collapsed shape, and wherein the adhesive layer is configured to at least partially degrade and thereby permit the plurality of surfaces to detach from one another and release the mechanical load, the structure configured so that when the mechanical load is released the structure reshapes itself from the collapsed shape into a second configuration having an original shape corresponding to a shape the structure had prior to the surfaces being joined together by the adhesive layer. ### Claim 2 (depends on 1) The structure of claim 1, wherein the adhesive layer is biocompatible and/or biodegradable. ### Claim 3 (depends on 1) The structure of claim 1, configured as a medical device. ### Claim 4 (depends on 1) The structure of claim 1, configured as an implantable medical device. ### Claim 5 (depends on 1) The structure of claim 1, configured as a stent. ### Claim 6 (depends on 1) The structure of claim 1, configured for a gradual release of the mechanical load by modulating a degradation rate of the adhesive layer. ### Claim 7 (depends on 1) The structure of claim 1, configured to release at least one chemical substance upon being reshaped due to at least partial degradation of the adhesive layer. ### Claim 8 (depends on 7) The structure of claim 7, wherein the chemical substance comprises at least one pharmaceutically active agent. ### Claim 9 (depends on 1) The structure of claim 1, wherein the adhesive layer comprises at least one ALD-deposited coating layer made of any of aluminium oxide (Al2O3), magnesium oxide (MgO), and silicon dioxide (SiO2). ### Claim 10 (depends on 1) The structure of claim 1, formed of a mesh wire. ### Claim 11 (depends on 1) The structure of claim 1, wherein the pre-applied mechanical load is a spring load. ### Claim 12 A method for manufacturing a structure, comprising: obtaining a structure having a plurality of surfaces, said structure configured to have an original shape; applying an adhesive to all surfaces of the structure by Atomic Layer Deposition (ALD); and joining said surfaces together with the adhesive so that said structure assumes a collapsed shape different from said original shape, wherein the structure is configured to bear a mechanical load when in the collapsed shape and held by the adhesive, and wherein the adhesive is configured to at least partially degrade in order to permit release of the mechanical load and thereby cause the collapsed structure to reshape and acquire the original shape that the structure had prior to the surfaces being joined together. ### Claim 13 A method for delivering at least one pharmaceutically active agent into the body, wherein said at least one pharmaceutically active agent is provided in a structure comprising a plurality of surfaces joined together with an adhesive provided in the form of a coating layer applied by Atomic Layer Deposition (ALD), wherein said structure is configured to release said pharmaceutically active agent upon at least partial degradation of the adhesive in the body. ### Claim 14 (depends on 13) The method of claim 13, wherein the structure is configured to release said at least one pharmaceutically active agent upon being reshaped by virtue of at least partial degradation of the adhesive in the body. ### Claim 15 (depends on 1) A medical device comprising the structure of claim 1. ### Claim 16 (depends on 15) The medical device of claim 15, wherein the medical device is implantable.