# US 11,992,358 B2 · Multimodality anthropomorhic phantom apparatus > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,992,358 B2 - Document ID: US11992358B2 - Status: Granted - Kind: B2 - Application number: 17/429,190 - Filed: 2020-02-13 - Published: 2022-05-05 - Granted: 2024-05-28 - Earliest claimed: 2019-02-13 - Assignees: The Regents of the University of California - Applicants: The Regents of the University of California - Inventors: Kamal Singhrao; John H. Lewis - Web page: https://patentgrep.com/patent/US11992358B2 ## CPC - A61B 6/583: {using calibration phantoms} - G01R 33/58: Calibration of imaging systems, e.g. using test probes {, Phantoms; Calibration objects or fiducial markers such as active or passive RF coils surrounding an MR active material} - G09B 23/30: Anatomical models {(G09B23/281 - G09B23/288 take precedence)} - G09B 23/286: {for scanning or photography techniques, e.g. X-rays, ultrasonics} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - G01R: MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES (indicating correct tuning of resonant circuits H03J3/12) - G09B: EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS (devices for psychotechnics or for testing reaction times A61B5/16; games, sports, amusements A63; projectors, projector screens G03B) ## Abstract A multimodality phantom apparatus includes a housing and a system of materials disposed within the housing. The system of material includes a first amount of abase material, a second amount of glass microspheres, a third amount of CaCO3, a fourth amount of gadolinium contrast and a fifth amount of agarose. The housing may include a plurality of compartments and at least one slot. The system of materials may be disposed within at least one compartment. The slot may be used to receive a dosimeter. ## Claims ### Claim 1 A multimodality phantom apparatus comprising: a housing; and a system of materials disposed within the housing and comprising: a first amount of a base material; a second amount of glass microspheres; a third amount of CaCO3; a fourth amount of gadolinium contrast and a fifth amount of agarose; wherein the second amount of glass microspheres, third amount of CaCO3, fourth amount of gadolinium contrast, and fifth amount of agarose are determined by optimization of a regression model over parameters T1, T2, and CT number. ### Claim 2 (depends on 1) The multimodality phantom apparatus according to claim 1, where the housing has a shape of a human organ. ### Claim 3 (depends on 1) The multimodality phantom apparatus according to claim 1, wherein the glass microspheres are configured to control electron density. ### Claim 4 (depends on 3) The multimodality phantom apparatus according to claim 3, wherein the glass microspheres are configured to diminish CT number values. ### Claim 5 (depends on 1) The multimodality phantom apparatus according to claim 1, wherein the CaCO3 is configured to control electron density. ### Claim 6 (depends on 5) The multimodality phantom apparatus according to claim 5, wherein the CaCO3 is configured to increase CT number values. ### Claim 7 (depends on 1) The multimodality phantom apparatus according to claim 1, wherein the gadolinium contrast is configured to control T1 behavior. ### Claim 8 (depends on 1) The multimodality phantom apparatus according to claim 1, wherein the agarose is configured to control T2 behavior. ### Claim 9 (depends on 1) The multimodality phantom apparatus according to claim 1, wherein the apparatus is configured for use with MR imaging and CT imaging. ### Claim 10 (depends on 1) The multimodal phantom apparatus according to claim 1, wherein the base material is a carrageenan based gelatinizer. ### Claim 11 A multimodality phantom comprising: a housing having a plurality of compartments and at least one slot, the slot configured to receive a dosimeter; and a system of materials disposed within at least one compartment in the plurality of compartments, the system of materials comprising: a first amount of a base material; a second amount of glass microspheres; a third amount of CaCO3; a fourth amount of gadolinium contrast and a fifth amount of agarose; wherein the second amount of glass microspheres, third amount of CaCO3, fourth amount of gadolinium contrast, and fifth amount of agarose are determined by optimization of a regression model over parameters T1, T2, and CT number. ### Claim 12 (depends on 11) The multimodality phantom according to claim 11, wherein at least one compartment has a shape of a human organ. ### Claim 13 (depends on 11) The multimodality phantom according to claim 11, wherein the phantom is configured for use with MR imaging and CT imaging. ### Claim 14 (depends on 11) The multimodality phantom according to claim 11, wherein the at least one slot is further configured to house at least one radiation measurement device. ### Claim 15 (depends on 11) The multimodality phantom according to claim 11, wherein the phantom is configured for use with MR-based radiotherapy. ### Claim 16 (depends on 11) The multimodality phantom according to claim 11, wherein the phantom is configured for use to test synthetic CT generation. ### Claim 17 (depends on 11) The multimodality phantom according to claim 11, wherein the phantom is configured for use with MR-CT imaging applications. ### Claim 18 (depends on 11) The multimodality phantom according to claim 11, wherein the system of materials is formed to have a shape of a human organ. ### Claim 19 (depends on 11) The multimodality phantom according to claim 11, wherein at least one compartment of the plurality of compartments has at least one rigid wall. ### Claim 20 (depends on 11) The multimodality phantom according to claim 11, wherein the at least one compartment of the plurality of compartments has at least one deformable wall.