# US 11,992,326 B2 · Method and system for measuring perspiration > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,992,326 B2 - Document ID: US11992326B2 - Status: Granted - Kind: B2 - Application number: 17/486,194 - Filed: 2021-09-27 - Published: 2022-01-13 - Granted: 2024-05-28 - Earliest claimed: 2016-04-19 - Assignees: Medidata Solutions, Inc. - Applicants: Medidata Solutions, Inc. - Inventors: Roozbeh Ghaffari; Gilbert Lee Huppert; Brian Murphy; Isaiah Kacyvenski - Web page: https://patentgrep.com/patent/US11992326B2 ## CPC - A61B 5/4266: {sweat secretion} - A61B 5/14517: {for sweat} - A61B 5/6833: {Adhesive patches} - A61B 5/002: {Monitoring the patient using a local or closed circuit, e.g. in a room or building (A61B5/0017 takes precedence)} - A61B 5/14532: {for measuring glucose, e.g. by tissue impedance measurement} - A61B 5/14539: {for measuring pH} - A61B 5/14546: {for measuring analytes not otherwise provided for, e.g. ions, cytochromes} - A61B 5/6824: {Arm or wrist} - A61B 2560/0223: of calibration, e.g. protocols for calibrating sensors - A61B 2560/0238: Means for recording calibration data - A61B 2560/0247: for compensation or correction of the measured physiological value - A61B 2560/0271: using a remote monitoring unit - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract A perspiration sensing system includes a sensor patch and a smart device. The sensor patch includes one or more perspiration sensing portions. The one or more perspiration sensing portions include an inlet having a predefined size to receive perspiration from a predefined number of sweat glands and an outlet for reducing back pressure. At least one perspiration sensing portion includes a channel having a colorimetric sensing material that changes color when exposed to perspiration. At least one perspiration sensing portion includes a colorimetric assay in a substrate that changes color when exposed to biochemical components of perspiration. The system further includes a smart device having a camera that can take a picture of the sensor patch and determine the volume, rate of perspiration, and/or biochemical components of the perspiration from the one or more perspiration sensing portions. ## Claims ### Claim 1 A sensor patch comprising: a perspiration volume sensing channel including at least a first colorimetric material that changes color in response to exposure to perspiration; a perspiration component sensing chamber including at least a second colorimetric material that changes color in response to exposure to a biochemical component in the perspiration; a near field communication circuit and a near field communication antenna; and a plurality of the perspiration component sensing chamber, each perspiration component sensing chamber including a chamber inlet port in fluid communication with the perspiration component sensing chamber to allow the perspiration to enter into the perspiration component sensing chamber, wherein two or more of the plurality of chamber inlet ports have different diameters to measure different collection rates of the perspiration. ### Claim 2 (depends on 1) The sensor patch of claim 1, further comprising: a channel inlet port in fluid communication with the perspiration volume sensing channel to allow the perspiration to enter into the perspiration volume sensing channel. ### Claim 3 (depends on 2) The sensor patch of claim 2, further comprising: a channel vent port in fluid communication with the perspiration volume sensing channel to reduce backpressure as the perspiration fills the perspiration volume sensing channel; and a chamber vent port in fluid communication with the perspiration component sensing chamber to reduce backpressure as the perspiration fills the perspiration component sensing chamber. ### Claim 4 (depends on 3) The sensor patch of claim 3, wherein the channel vent port vents out of a surface of the sensor patch opposite from the channel inlet port. ### Claim 5 (depends on 3) The sensor patch of claim 3, wherein the channel vent port vents to an outer edge of the sensor patch perpendicular to the channel inlet port. ### Claim 6 (depends on 1) The sensor patch of claim 1, further comprising: at least one indicia configured to have a shape, a size, a color, a location, or a combination thereof for calibrating an image of the sensor patch taken by a smart device. ### Claim 7 (depends on 1) The sensor patch of claim 1, further comprising: an adhesive layer configured to attach the sensor patch to a surface of a user. ### Claim 8 (depends on 7) The sensor patch of claim 7, further comprising an integrated circuit that includes the near field communication circuit. ### Claim 9 (depends on 1) The sensor patch of claim 1, wherein each perspiration component sensing chamber includes a chamber vent port in fluid communication with the perspiration component sensing chamber and directly in fluid communication with an environment of the sensor patch to reduce backpressure as the perspiration fills the perspiration component sensing chamber. ### Claim 10 (depends on 9) The sensor patch of claim 9, wherein the chamber inlet port is horizontally aligned with a corresponding chamber vent port and vertical axes defined by the chamber inlet port and the corresponding chamber vent port pass through a corresponding perspiration component sensing chamber for at least one of the plurality of the perspiration component sensing chamber. ### Claim 11 (depends on 9) The sensor patch of claim 9, further comprising: a channel inlet port in fluid communication with the perspiration volume sensing channel to allow the perspiration to enter into the perspiration volume sensing channel; and a channel vent port in fluid communication with the perspiration volume sensing channel to reduce backpressure as the perspiration fills the perspiration volume sensing channel, wherein the sensor patch has a bottom surface and a top surface opposite the bottom surface, and wherein the channel inlet port and the plurality of chamber inlet ports are on the bottom surface and the channel vent port and the plurality of chamber vent ports are on the top surface. ### Claim 12 A method of using a smart device and a sensor patch placed on a surface of a user to determine one or more properties of perspiration from the user, the method comprising: causing the smart device to interrogate a near field communication circuit of the sensor patch; executing a function on the smart device to obtain at least one image of the sensor patch based on data sent from the near field communication circuit in response to the interrogation; analyzing the at least one image to determine a volume of the perspiration, a rate of the perspiration, one or more components within the perspiration, or a combination thereof and determining a first length of a color change within a perspiration channel of the sensor patch; comparing the first length of the color change with a second length of the color change within the perspiration channel of the sensor patch from analysis of at least one other image of the sensor patch; and determining the rate of the perspiration based on the comparison of the first length to the second length. ### Claim 13 (depends on 12) The method of claim 12, further comprising: calibrating the at least one image based on one or more indicia visible on the sensor patch and captured in the at least one image. ### Claim 14 (depends on 13) The method of claim 13, wherein the calibration includes orienting and scaling the at least one image, adjusting a white balance of the at least one image based on a color of the one or more indicia, or a combination thereof. ### Claim 15 (depends on 12) The method of claim 12, wherein the analysis comprises determining a quantitative measure of one or more elements in the perspiration based on a color hue, a color value, a color intensity, or a combination thereof of a colorimetric material within a sensing chamber of the sensor patch. ### Claim 16 (depends on 12) The method of claim 12, further comprising: determining an amount of time between acquisition of the at least one image and the at least one other image based, at least in part, on date stamps, time stamps, or a combination thereof of the at least one image and the at least one other image, wherein the determination of the rate is based on the amount of time. ### Claim 17 (depends on 12) The method of claim 12, wherein the analysis comprises determining the volume of the perspiration based on a volume of the perspiration channel and the first length of the color change. ### Claim 18 (depends on 12) The method of claim 12, further comprising: determining, by the smart device, a temperature, a humidity, a pressure, a location, an elevation, or a combination thereof of an environment of the sensor patch as metadata; and tagging the at least one image with the metadata for use in the analysis of the at least one image. ### Claim 19 A method of using a smart device and a sensor patch placed on a surface of a user to determine one or more properties of perspiration from the user, the method comprising: causing the smart device to interrogate a near field communication circuit of the sensor patch; executing a function on the smart device to obtain at least one image of the sensor patch based on data sent from the near field communication circuit in response to the interrogation; and analyzing the at least one image to determine a volume of the perspiration, a rate of the perspiration, one or more components within the perspiration, or a combination thereof, wherein the analysis comprises determining a first length of a color change within a perspiration channel of the sensor patch and determining the volume of perspiration based on a volume of the perspiration channel and the first length of the color change. ### Claim 20 (depends on 19) The method of claim 19, further comprising: calibrating the at least one image based on one or more indicia visible on the sensor patch and captured in the at least one image. ### Claim 21 (depends on 20) The method of claim 20, wherein the calibration includes orienting and scaling the at least one image, adjusting a white balance of the at least one image based on a color of the one or more indicia, or a combination thereof. ### Claim 22 (depends on 19) The method of claim 19, wherein the analysis comprises determining a quantitative measure of one or more elements in the perspiration based on a color hue, a color value, a color intensity, or a combination thereof of a colorimetric material within a sensing chamber of the sensor patch. ### Claim 23 (depends on 19) The method of claim 19, further comprising: comparing the first length of the color change with a second length of the color change within the perspiration channel of the sensor patch from analysis of at least one other image of the sensor patch; determining the rate of the perspiration based on the comparison of the first length to the second length; and determining an amount of time between acquisition of the at least one image and the at least one other image based, at least in part, on date stamps, time stamps, or a combination thereof of the at least one image and the at least one other image, wherein the determination of the rate is based on the amount of time. ### Claim 24 (depends on 19) The method of claim 19, further comprising: determining, by the smart device, a temperature, a humidity, a pressure, a location, an elevation, or a combination thereof as metadata; and tagging the at least one image with the metadata for use in the analysis of the at least one image.