# US 11,992,302 B2 · System and method for non-invasively determining an indication and/or an assessment of intracranial pressure

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 11,992,302 B2
- Document ID: US11992302B2
- Status: Granted
- Kind: B2
- Application number: 17/396,015
- Filed: 2021-08-06
- Published: 2021-11-25
- Granted: 2024-05-28
- Earliest claimed: 2020-01-03
- Assignees: Vivonics, Inc.
- Applicants: Vivonics, Inc.
- Inventors: Michele Pierro
- Web page: https://patentgrep.com/patent/US11992302B2

## CPC

- A61B 5/031: {Intracranial pressure}
- A61B 5/0059: {using light, e.g. diagnosis by transillumination, diascopy, fluorescence (photoacoustic A61B5/0093; optical measurement of heart rate A61B5/02416; optical measurement of blood flow A61B5/0261; optical measurement of analytes A61B5/1455)}
- A61B 5/14542: {for measuring blood gases (A61B5/14551 takes precedence)}
- A61B 5/14553: {specially adapted for cerebral tissue}
- A61B 5/6814: {Head}
- A61B 5/0075: {by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy (A61B5/0071 takes precedence)}
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

A system for non-invasively determining an indication and/or an assessment of intracranial pressure (ICP) is featured. The system includes at least one intracranial light source adapted to be placed on skin above a cranium of a living subject configured to emit light which penetrates the cranium and targets intracranial space of a living subject. The system includes a least one extracranial light source adapted to be placed on skin above a predetermined area of the living subject configured to emit light which penetrates and targets extracranial space of the living subject. A detector subsystem including at least a first detector is configured to detect reflected light from the intracranial space and the extracranial space and is configured to output intracranial output signals associated with light detected from the intracranial space and/or output extracranial output signals associated with light detected from the extracranial space. A processing subsystem is coupled to the at least one intracranial light source, the at least one extracranial light source, and the detector subsystem. The processing subsystem is configured to determine intracranial oxygen saturation and extracranial oxygen saturation and non-invasively determine an indication and/or an assessment of ICP using a ratio of the intracranial oxygen saturation to the extracranial oxygen saturation.

## Claims

### Claim 1

A system for non-invasively determining an indication and/or an assessment of intracranial pressure (ICP), the system comprising:
at least one first light-based sensor and a measuring apparatus that determines intracranial or cerebral oxygen saturation in response to reflected light detected from intracranial space of a living subject;
at least one second light-based sensor and the measuring apparatus that determines extracranial or extracerebral oxygen saturation in response to reflected light detected from extracranial space of the living subject; and
a processing subsystem coupled to the at least one first light-based sensor, the measuring apparatus, and the at least one second light-based sensor, the processing subsystem configured to determine the indication and/or the assessment of ICP using a ratio of the intracranial oxygen saturation to the extracranial oxygen saturation.

### Claim 2

A method for non-invasively determining an indication and/or an assessment of intracranial pressure (ICP), the method comprising:
determining intracranial or cerebral oxygen saturation in response to reflected light detected from intracranial space of a living subject;
determining extracranial or extracerebral oxygen saturation in response to reflected light detected from extracranial space of the living subject; and
determining the indication and/or the assessment of ICP using a ratio of the intracranial oxygen saturation to the extracranial oxygen saturation.