# US 11,992,211 B2 · Systems and methods of tissue closure > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,992,211 B2 - Document ID: US11992211B2 - Status: Granted - Kind: B2 - Application number: 17/829,095 - Filed: 2022-05-31 - Published: 2022-09-15 - Granted: 2024-05-28 - Earliest claimed: 2006-05-03 - Assignees: Datascope Corporation - Applicants: Datascope Corp. - Inventors: William K. Wheeler; Ashik A. Mohan - Web page: https://patentgrep.com/patent/US11992211B2 ## CPC - A61B 17/072: for applying a row of staples in a single action, e.g. the staples being applied simultaneously - A61B 17/064: Surgical staples, {i.e. penetrating the tissue} - A61B 17/0643: {with separate closing member, e.g. for interlocking with staple} - A61B 17/122: Clamps or clips, e.g. for the umbilical cord {(for the vas deferens A61F6/206)} - A61B 17/1285: {for minimally invasive surgery} - A61B 2017/00243: {cardiac} - A61B 2017/0647: {having one single leg, e.g. tacks} - A61B 2017/07214: {Stapler heads} - A61B 2017/306: {holding by means of suction} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract Apparatus, systems, and methods are described for closing the base of a left atrial appendage or other tissue structure. A tissue closure device comprises a pair of legs having compliant surfaces for engaging against opposite sides of the tissue structure. A plurality of axially spaced-apart tissue-penetrating fasteners are delivered from one leg to the other to pierce the intervening tissue and hold the closure device in place on the tissue structure. ## Claims ### Claim 1 A method for closing a tissue structure, said method comprising: positioning a compression body over the tissue structure with at least two compliant tissue-engaging surfaces engaging opposite sides of the structure; deploying fasteners from at least one of said surfaces, through the tissue, and into the other surface to close the tissue structure; and excising the tissue structure at a location above the compression body after the fasteners have been deployed. ### Claim 2 (depends on 1) The method as in claim 1, wherein the tissue structure is a left atrial appendage. ### Claim 3 (depends on 2) The method as in claim 2, wherein positioning comprises intercostally advancing the compression member. ### Claim 4 (depends on 2) The method as in claim 2, wherein positioning comprises carrying the compliant compression body on an applicator, spreading the tissue-engaging surfaces using the applicator, and closing the spread legs over the tissue structure. ### Claim 5 (depends on 1) The method as in claim 1, wherein deploying fasteners comprises advancing male elements from either or both of the tissue-engaging surface(s) to female elements in the opposed tissue-engaging surface. ### Claim 6 (depends on 1) The method as in claim 1, wherein deploying fasteners comprises advanced barbed needles from one tissue-engaging surface to the other tissue-engaging surface. ### Claim 7 (depends on 1) The method as in claim 1, further comprising viewing the tissue structure through an optical scope during at least a portion of the procedure. ### Claim 8 (depends on 1) The method as in claim 1, further comprising directly viewing the tissue structure through a percutaneous opening during at least a portion of the procedure. ### Claim 9 (depends on 1) The method as in claim 1, further comprising introducing a substance to the tissue structure through the compression body. ### Claim 10 (depends on 9) The method as in claim 9, wherein the substance is an antibiotic, an antiseptic, or an anti-inflammatory. ### Claim 11 A method for closing a tissue structure, said method comprising: positioning a compression body over the tissue structure with at least two compliant tissue-engaging surfaces engaging opposite sides of the structure; and deploying fasteners from at least one of said surfaces, through the tissue, and into the other surface to close the tissue structure, wherein the fasteners do not extend out of the compression body after deployment. ### Claim 12 (depends on 11) The method as in claim 11, wherein the fasteners are deployed to close the tissue-engaging surfaces against the tissue with a pressure in the range from 0.25 psi to 1.5 psi. ### Claim 13 (depends on 11) The method as in claim 11, wherein the tissue structure is a left atrial appendage. ### Claim 14 (depends on 13) The method as in claim 13, wherein positioning comprises intercostally advancing the compression member. ### Claim 15 (depends on 13) The method as in claim 13, wherein positioning comprises carrying the compliant compression body on an applicator, spreading the tissue-engaging surfaces using the applicator, and closing the spread legs over the tissue structure. ### Claim 16 (depends on 11) The method as in claim 11, wherein deploying fasteners comprises advancing male elements from either or both of the tissue-engaging surface(s) to female elements in the opposed tissue-engaging surface. ### Claim 17 (depends on 11) The method as in claim 11, wherein deploying fasteners comprises advanced barbed needles from one tissue-engaging surface to the other tissue-engaging surface. ### Claim 18 (depends on 11) The method as in claim 11, further comprising viewing the tissue structure through an optical scope during at least a portion of the procedure. ### Claim 19 (depends on 11) The method as in claim 11, further comprising directly viewing the tissue structure through a percutaneous opening during at least a portion of the procedure. ### Claim 20 (depends on 11) The method as in claim 11, further comprising introducing a substance to the tissue structure through the compression body, wherein the substance is an antibiotic, an antiseptic, or an anti-inflammatory.