# US 11,992,038 B2 · Liquid nicotine formulation comprising partially water-soluble solvent > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,992,038 B2 - Document ID: US11992038B2 - Status: Granted - Kind: B2 - Application number: 17/419,374 - Filed: 2019-12-31 - Published: 2022-03-10 - Granted: 2024-05-28 - Earliest claimed: 2018-12-31 - Assignees: Philip Morris Products S.A. - Applicants: Philip Morris Products S.A. - Inventors: Jean-Pierre Schaller; Aline Vuarnoz-Bize - Web page: https://patentgrep.com/patent/US11992038B2 ## CPC - A24B 15/167: in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes - A24B 15/28: by chemical substances - A24B 15/32: by acyclic compounds - A24F 40/05: Devices without heating means - A24F 40/10: Devices using liquid inhalable precursors - A24F 40/46: Shape or structure of electric heating means - A61K 9/0078: {for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions} - A61K 9/12: Aerosols; Foams {(A61K9/0043, A61K9/0056, A61K9/006, A61K9/0073 take precedence; spray-films A61K9/7015)} - A61K 31/465: Nicotine; Derivatives thereof - A24B: MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF - A24F: SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES (inhaling appliances for medical purposes, shaped like cigars, cigarettes or pipes A61M15/06) - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) ## Abstract A liquid nicotine formulation for an aerosol-generating system is provided, the liquid nicotine formulation including: water; and one or more partially water-soluble, water-immiscible solvents having a water solubility at 20° C. of between about 20 mg/ml and about 100 mg/ml, the liquid nicotine formulation having a water content of greater than or equal to about 5 percent by weight and a partially water-soluble, water-immiscible solvent content of between about 2 percent by weight and about 30 percent by weight. A cartridge for an aerosol-generating system, and an aerosol-generating system, are also provided. ## Claims ### Claim 1 A liquid nicotine formulation for an aerosol-generating system, the liquid nicotine formulation comprising: water; and one or more partially water-soluble, water-immiscible solvents having a water solubility at 20° C. of between about 20 mg/ml and about 100 mg/ml, wherein the liquid nicotine formulation has a water content of greater than or equal to about 5 percent by weight and a partially water-soluble, water-immiscible solvent content of between about 2 percent by weight and about 30 percent by weight. ### Claim 2 (depends on 1) The liquid nicotine formulation according to claim 1, further comprising one or more water-insoluble, water-immiscible solvents having a water solubility at 20° C. of less than or equal to about 5 mg/ml. ### Claim 3 (depends on 1) The liquid nicotine formulation according to claim 1, wherein the liquid nicotine formulation has a partially water-soluble, water-immiscible solvent content of greater than or equal to about 2.5 percent by weight. ### Claim 4 (depends on 1) The liquid nicotine formulation according to claim 1, wherein the one or more partially water-soluble, water-immiscible solvents are selected from the group consisting of triacetin and triethyl citrate. ### Claim 5 (depends on 1) The liquid nicotine formulation according to claim 1, further comprising one or more solid emulsifiers. ### Claim 6 (depends on 1) The liquid nicotine formulation according to claim 1, further comprising one or more water-soluble organic acids, wherein the liquid nicotine formulation has a water-soluble organic acid content of greater than or equal to about 2 percent by weight. ### Claim 7 (depends on 1) An aerosol-generating system, comprising: a liquid nicotine formulation according to claim 1; and an atomiser configured to generate an aerosol from the liquid nicotine formulation. ### Claim 8 (depends on 1) The liquid nicotine formulation according to claim 1, further comprising water and one or more water-miscible solvents. ### Claim 9 (depends on 8) The liquid nicotine formulation according to claim 8, wherein the liquid nicotine formulation has a total water and water-miscible solvent content of greater than or equal to about 60 percent by weight. ### Claim 10 (depends on 8) The liquid nicotine formulation according to claim 8, wherein the one or more water-miscible solvents are one or more water-miscible polyhydric alcohols selected from the group consisting of 1,3-butanediol, glycerine, propylene glycol, and triethylene glycol. ### Claim 11 (depends on 1) A cartridge for an aerosol-generating system, the cartridge containing a liquid nicotine formulation according to claim 1. ### Claim 12 (depends on 11) The cartridge according to claim 11, further comprising an atomiser configured to generate an aerosol from the liquid nicotine formulation. ### Claim 13 A liquid nicotine formulation for an aerosol-generating system, the liquid nicotine formulation comprising: water; and one or more partially water-soluble, water-immiscible solvents having a partition coefficient (log P) at 20° C. of between about 0.05 and about 0.5, wherein the liquid nicotine formulation has a water content of greater than or equal to about 5 percent by weight and a partially water-soluble, water-immiscible solvent content of between about 2 percent by weight and about 30 percent by weight. ### Claim 14 (depends on 13) The liquid nicotine formulation according to claim 13, further comprising one or more water-insoluble, water-immiscible solvents having a partition coefficient (log P) at 20° C. of greater than about 5.