# US 11,992,035 B2 · Cohesive thin liquids to promote safe swallowing in dysphagic patients

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- Number: US 11,992,035 B2
- Document ID: US11992035B2
- Status: Granted
- Kind: B2
- Application number: 16/790,286
- Filed: 2020-02-13
- Published: 2020-06-25
- Granted: 2024-05-28
- Earliest claimed: 2011-12-15
- Assignees: Societe des Produits Nestle S.A.
- Applicants: Société des Produits Nestlé S.A.
- Inventors: Adam Stewart Burbidge; Jan Engmann; Simina Popa Nita
- Web page: https://patentgrep.com/patent/US11992035B2

## CPC

- A23L 29/271: {Curdlan; beta-1-3 glucan; Polysaccharides produced by agrobacterium or alcaligenes}
- A23L 29/20: containing gelling or thickening agents (marmalades, jams, jellies or other similar fruit or vegetable compositions A23L21/10)
- A23L 29/206: of vegetable origin
- A23L 29/238: from seeds, e.g. locust bean gum or guar gum (starch A23L29/212; pectin A23L29/231)
- A23L 29/256: from seaweeds, e.g. alginates, agar or carrageenan
- A23L 29/27: {Xanthan not combined with other microbial gums}
- A23L 29/272: {Gellan}
- A23L 33/10: using additives (addition of substantially indigestible substances A23L33/21)
- A23L 33/105: Plant extracts, their artificial duplicates or their derivatives
- A23L 33/115: Fatty acids or derivatives thereof; Fats or oils
- A23L 33/135: Bacteria or derivatives thereof, e.g. probiotics
- A23L 33/15: Vitamins
- A23L 33/175: Amino acids
- A23L 33/21: Addition of substantially indigestible substances, e.g. dietary fibres
- A61K 31/715: Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K 36/185: Magnoliopsida (dicotyledons)
- A61K 36/577: {Malvaceae (Mallow family)}
- A61P 1/00: Drugs for disorders of the alimentary tract or the digestive system
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

Nutritional products having improved cohesiveness for promoting safer swallowing of food boluses for patients having swallowing conditions are provided as well as methods of making and using such products. The nutritional products may include nutritional compositions and high molecular weight, water-soluble polymers such that the nutritional products have extensional viscosities that provide improved cohesiveness to the nutritional products. Methods of administering such nutritional products to patients having impaired swallowing ability and/or dysphagia are also provided.

## Claims

### Claim 1

A method of treating an individual having a swallowing disorder, the method comprising:
administering an effective amount of a liquid nutritional product to the individual having the swallowing disorder, the liquid nutritional product comprising a nutritional composition and a plant-derived mucilage selected from the group consisting of kiwi fruit mucilage, mallow mucilage, ribwort mucilage, mullein mucilage, and mixtures thereof, the liquid nutritional product comprises an amount of the plant-derived mucilage such that the liquid nutritional product has an increased cohesiveness relative to the nutritional composition, has a shear viscosity less than about 100 mPas when measured at a shear rate of 50s−1 and has a relaxation time, determined by a Capillary Breakup Extensional Rheometry (CaBER) experiment, more than 10 milliseconds at a temperature of 20° C.

### Claim 2 (depends on 1)

The method of claim 1, wherein the shear viscosity of the liquid nutritional product is 5 mPas to 20 mPas when measured at a shear rate of 50s−1.

### Claim 3 (depends on 1)

The method of claim 1, wherein the relaxation time of the liquid nutritional product is about 100 milliseconds to about 200 milliseconds.

### Claim 4 (depends on 1)

The method of claim 1, wherein the swallowing disorder is at least one of dysphagia or compromised saliva excretion.

### Claim 5 (depends on 1)

The method of claim 1, wherein the liquid nutritional product has a form selected from the group consisting of pharmaceutical formulations, nutritional formulations, dietary supplements, functional food and beverage products, and combinations thereof.

### Claim 6 (depends on 1)

The method of claim 1, wherein the liquid nutritional product further comprises an additional ingredient selected from the group consisting of a probiotic, a prebiotic, an amino acid, a fatty acid, a phytonutrient, an antioxidant, and mixtures thereof.

### Claim 7 (depends on 1)

The method of claim 1, wherein the plant-derived mucilage comprises kiwi fruit mucilage.