# US 11,992,011 B2 · Compounds for controlling plant pathogens

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- Number: US 11,992,011 B2
- Document ID: US11992011B2
- Status: Granted
- Kind: B2
- Application number: 16/954,976
- Filed: 2018-12-20
- Published: 2020-10-01
- Granted: 2024-05-28
- Earliest claimed: 2017-12-21
- Assignees: Universiteit Gent; Vib Vzw; Taminco
- Applicants: Vib Vzw; Universiteit Gent; Taminco BV
- Inventors: Willem Desmedt; Tina Kyndt; Bartel Vanholme
- Web page: https://patentgrep.com/patent/US11992011B2

## CPC

- A01N 43/40: six-membered rings
- A01N 25/00: Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application {, e.g. seed treatment or sequential application}; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N 25/06: Aerosols
- A01N 25/30: characterised by the surfactants
- A01N 37/10: Aromatic or araliphatic carboxylic acids, or thio analogues thereof; Derivatives thereof
- A01N 37/36: containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
- A01N 37/40: having at least one carboxylic group or a thio analogue, or a derivative thereof, and one oxygen or sulfur atom attached to the same aromatic ring system
- A01N 43/30: with two oxygen atoms in positions 1,3, condensed with a carbocyclic ring
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS

## Abstract

The present invention is in the field of agricultural pathogen control. More specifically the invention relates to compounds capable of inhibiting cinnamate-4-hydroxylase and their use for protecting plants against plant pathogens, in particular against nematodes, fungi and/or bacteria. The invention also provides for compositions comprising the same, methods of making the same, and methods of controlling plant disease.

## Claims

### Claim 1

A method for controlling and/or treating nematode infections in plants, said method comprising applying an effective amount of a compound to a plant or part thereof, or to the soil, substrate or water surrounding the plant, wherein said compound is selected from piperonylic acid (PA), or a stereoisomer, tautomer, hydrate, salt, ester and/or solvate thereof.

### Claim 2 (depends on 1)

The method according to claim 1, wherein the nematode is a root knot nematode, a root-lesion nematode or a cyst nematode.

### Claim 3 (depends on 1)

The method according to claim 1, wherein the nematode belongs to the genus selected from the group consisting of: Meloidogyne, Heterodera, Globodera, Pratylenchus, Aphelenchoides, Xiphinema, Radolpholus, Bursaphelenchus, Rotylenchulus, Nacobbus, Longidorus, Ditylenchus and Trichodorus.

### Claim 4 (depends on 1)

The method according to claim 1, wherein the compound is used in a concentration between),1 μM and 1000 μM.

### Claim 5 (depends on 1)

The method according to claim 1, wherein the compound is formulated as part of a composition which further comprises a diluent, an additive, a plant nutrient, an emulsion stabilizer, a surfactant, a buffer, a crop oil, a drift inhibitor and/or a substratum.

### Claim 6 (depends on 1)

The method according to claim 1, wherein the compound is applied to the leaves of the plant, as a coat to the seeds of the plant, or as a soil or root drench.

### Claim 7 (depends on 1)

The method according to claim 1, wherein the compound is applied by high or low-pressure spraying, immersion, atomizing, foaming, fogging, coating, or encrusting.

### Claim 8 (depends on 1)

The method according to claim 1, wherein the compound is applied two or more times.

### Claim 9 (depends on 1)

The method according to claim 1, wherein the compound is in a composition that further comprises a herbicide, insecticide, nematicide, molluscicide, bactericide, acaricide, fungicide, and/or plant growth regulator or fertilizer.

### Claim 10

A method for controlling and/or treating oomycete infection in plants, said method comprising applying an effective amount of a compound to a pant or part thereof, or to the soil, substrate or water surrounding the plant, wherein said compound is selected from piperonylic acid, or a salt thereof, and wherein oomycete is Pythium splendens.