Protein biomarker indicators of neurological injury and/or disease and methods of use thereof
AssigneeBrainbox Solutions, Inc.
InventorTimothy E. Van Meter
Life of this patent
Estimating the term…
Abstract
Methods, compositions and kits useful in the detection, assessment, diagnosis, prognosis and/or treatment of neurological injury or disease or brain injury, such as traumatic brain injury (TBI), are provided in which certain newly discovered protein biomarkers are detected in a biological sample of a subject undergoing testing or evaluation. The methods allow for detection of changes in levels, amounts, or concentrations of the protein biomarkers in a subject compared with those of controls. Detection of the protein biomarkers, and/or levels thereof, provides an indication of biological and biochemical events, e.g., at a cellular level, that are occurring in the subject who is undergoing testing or analysis for the neurological injury or brain injury.
Claims14
A method of detecting two or more protein biomarkers, or fragments thereof, in a biofluid sample obtained from a subject having, or suspected of having, a traumatic brain injury, the method comprising the steps of:
- A) obtaining the biofluid sample from the patient;
- and
- B) detecting von Willebrand Factor (vWF) and Astrotactin 2 (ASTN2) in the biofluid sample by an assay or mass spectrometry.
Dependencies are inferred from the claim text.