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US 11,988,652 B2Granted
Packed tip electrospray emitter
AssigneeThermo Finnigan LLC
InventorsJoshua A. Silveira, Dale Lindseth, Gary A. Schultz, Eloy R. Wouters, Michael L. Poltash, Brandon Howard Robson
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Abstract
Packed-tip electrospray ionization (ESI) emitters for mass spectrometry are described. In one aspect an ESI emitter stores a first type of particle. A liquid chromatography (LC) column is coupled with the emitter via a junction. The LC column stores a different type of particle than the ESI emitter to facilitate better chromatographic and ESI performance.
Claims30
An apparatus for analyzing a sample with a mass spectrometer, comprising:
- an electrospray ionization (ESI) emitter having first particles disposed within;
- a junction coupled with the emitter;
- and
- a liquid chromatography (LC) column coupled with the junction, the LC column having second particles disposed within, the first particles and the second particles being different types of particles, and wherein the first particles are more electrically conductive than the second particles.
1 more element
A method of operating a mass spectrometer to analyze a sample, comprising:
- introducing the sample to a liquid chromatography (LC) column having first particles disposed within;
- eluting the sample from the LC column to an electrospray ionization (ESI) emitter through a junction coupling the LC column with the ESI emitter, the ESI emitter having second particles disposed within, wherein the first particles are more electrically conductive than the second particles;
- and
- generating, using the ESI emitter, ions from the sample.
1 more element
An apparatus, comprising:
- a chromatography column having first particles disposed within;
- and
- an electrospray ionization (ESI) emitter having second particles disposed within, and configured to receive a sample from the chromatography column and generate ions from the sample for mass analysis, wherein the first particles are more electrically conductive than the second particles.
Dependencies are inferred from the claim text.