US 11,988,636 B2Granted

Method for particle analysis and method for particle production

AssigneesKAWANO Lab. Inc., TableMark Co., Ltd.

InventorsMakoto Kawano, Ayako Tatematsu, Ryosuke Abe

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Abstract

The method for particle analysis includes a first magnetic susceptibility measurement step S4 of measuring a volume magnetic susceptibility of each of first particles p1; an encapsulation treatment step S5 of performing an encapsulation treatment so that the first particles p1 encapsulate an encapsulation target component pt smaller than the first particles p1; a second magnetic susceptibility measurement step S8 of measuring a volume magnetic susceptibility of each of second particles p2 as an analysis target that are the first particles p1 after the encapsulation treatment; and a step S9 of analyzing whether or not the encapsulation target component pt is encapsulated in the second particles p2 based on a result of measurement in the first magnetic susceptibility measurement step S4 and a result of measurement in the second magnetic susceptibility measurement step S8.

Claims6

Dependent claims

A method for particle analysis, the method comprising:

a first observation step of observing first particles subjected to magnetophoresis;
a first migration velocity measurement step of measuring a magnetophoretic velocity of the first particles based on an observation result in the first observation step;
a first magnetic susceptibility measurement step of measuring a volume magnetic susceptibility of each of the first particles based on a result of measurement in the first migration velocity measurement step;
an encapsulation treatment step of performing an encapsulation treatment so that the first particles encapsulate an encapsulation target component smaller than the first particles;
a second observation step of observing second particles that are the first particles after the encapsulation treatment subjected to magnetophoresis;
a second migration velocity measurement step of measuring a magnetophoretic velocity of the second particles based on an observation result in the second observation step;
a second magnetic susceptibility measurement step of measuring a volume magnetic susceptibility of each of the second particles based on a result of measurement in the second migration velocity measurement step;
a step of analyzing whether or not the encapsulation target component is encapsulated in the second particles based on a result of measurement in the first magnetic susceptibility measurement step and a result of measurement in the second magnetic susceptibility measurement step;
a first zeta potential measurement step of measuring a zeta potential of the first particles;
a second zeta potential measurement step of measuring a zeta potential of the second particles;
and
a step of analyzing whether or not the encapsulation target component is encapsulated in the second particles based on a result of measurement in the first zeta potential measurement step and a result of measurement in the second zeta potential measurement step.

9 more elements

A method for particle production, the method comprising:

a first observation step of observing first particles subjected to magnetophoresis;
a first migration velocity measurement step of measuring a magnetophoretic velocity of the first particles based on an observation result in the first observation step;
a first magnetic susceptibility measurement step of measuring a volume magnetic susceptibility of each of the first particles based on a result of measurement in the first migration velocity measurement step;
an encapsulation treatment step of performing an encapsulation treatment so that the first particles encapsulate an encapsulation target component smaller than the first particles;
a second observation step of observing second particles that are the first particles after the encapsulation treatment subjected to magnetophoresis;
a second migration velocity measurement step of measuring a magnetophoretic velocity of the second particles based on an observation result in the second observation step;
a second magnetic susceptibility measurement step of measuring a volume magnetic susceptibility of each of the second particles based on a result of measurement in the second migration velocity measurement step;
a step of analyzing whether or not the encapsulation target component is encapsulated in the second particles based on a result of measurement in the first magnetic susceptibility measurement step and a result of measurement in the second magnetic susceptibility measurement step;
a first zeta potential measurement step of measuring a zeta potential of the first particles;
a second zeta potential measurement step of measuring a zeta potential of the second particles;
and
a step of analyzing whether or not the encapsulation target component is encapsulated in the second particles based on a result of measurement in the first zeta potential measurement step and a result of measurement in the second zeta potential measurement step.

9 more elements

Dependencies are inferred from the claim text.

Facts

Application: 16/858,432Filed 24 Apr 2020
Published: US 2020/0340947 A129 Oct 2020
Granted: 21 May 2024
Term ends: Not estimatedThe source records don’t support an estimate.

Classification24 codes

G01N 27/76
Of fluids: by investigating susceptibility
G01N 33/56961
For microorganisms, e.g. protozoa, bacteria, viruses: plant cells or fungi
A23L 27/72
Fixation, conservation, or encapsulation of flavouring agents: encapsulation
A23P 10/30
Shaping or working of foodstuffs characterised by the products: encapsulation of particles, e.g. foodstuff additives