Biocompatible conditioned cell medium compositions and uses thereof
AssigneeCellum Biomedical, Inc.
InventorRichard C. Jin
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Abstract
The present invention is drawn, in part, to biocompatible compositions comprising a biocompatible polymer matrix and conditioned cell medium comprising i) a cell culture medium and ii) one or more agents synthesized by and secreted from one or more cells cultured in the cell culture medium, as well as therapeutic uses thereof, particularly in modulating bone and/or gum tissue growth.
Claims27
A method of treating a periodontal condition in a human subject, the method comprising administering to a periodontal site in need of a) gum and/or bone growth and/or b) gum erosion and/or bone resorption inhibition in the human subject an effective amount of a biocompatible composition comprising:
- (a) a biocompatible polymer matrix, wherein the polymer matrix is agarose;
- and
- (b) a conditioned cell medium comprising i) a cell culture medium and ii) one or more agents synthesized by and secreted from one or more cells cultured in the cell culture medium, wherein the cells are fibroblasts, dermal fibroblasts, neonatal dermal fibroblasts, osteoblasts, fibroblasts and osteoblasts cultured separately, and/or a co-culture of fibroblasts and osteoblasts.
Dependencies are inferred from the claim text.