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US 11,987,802 B2Granted
Oncolytic virus vector and application thereof
AssigneeShanghai Yunying Biopharmaceutical Technology Co., Ltd.
InventorsZiying Gong, Daoyun Zhang, Yonghua Sun, Yi Wang, Nan Shi, Jun Zhu, Miao Ding
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Abstract
The embodiments of the present disclosure may provide an oncolytic virus vector and an application thereof. The oncolytic virus vector may comprise a recombinant nucleic acid. The recombinant nucleic acid may include: (i) a first nucleic acid fragment encoding a soluble PD-1 molecule; (ii) a second nucleic acid fragment encoding a CD86 molecule; and (iii) a third nucleic acid fragment encoding an antibody to a CD3 molecule.
Claims9
An oncolytic virus containing a recombinant nucleic acid, wherein the recombinant nucleic acid comprises:
- (i) a first nucleic acid fragment encoding a soluble PD-1 molecule;
- (ii) a second nucleic acid fragment encoding a CD86 molecule;
- (iii) a third nucleic acid fragment encoding an antibody to a CD3 molecule;
- and
- (iv) a fourth nucleic acid fragment encoding a US11 protein, wherein:
- the oncolytic virus is an HSV-1 virus, and
- the recombinant nucleic acid has a sequence of SEQ ID NO:
- 5.
5 more elements
Dependencies are inferred from the claim text.