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US 11,987,792 B2Granted
Compositions and methods for inhibiting expression of the LECT2 gene
AssigneeAlnylam Pharmaceuticals, Inc.
InventorsGregory Hinkle, Huilei Xu
Life of this patent
Estimating the term…
Abstract
The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the LECT2 gene, and methods of using such dsRNA compositions to alter (e.g., inhibit) expression of LECT2.
Claims20
A double-stranded ribonucleic acid (dsRNA) for inhibiting expression of LECT2, wherein said dsRNA comprises a sense strand and an antisense strand, the antisense strand comprising a region of complementarity to a LECT2 RNA transcript, wherein the antisense strand comprises at least 15 contiguous nucleotides differing by no more than 3 nucleotides from the antisense sequence and all the modifications of SEQ ID NO:
- 93 or 290 and the sense strand comprises at least 15 contiguous nucleotides differing by no more than 3 nucleotides from the sense sequence and all the modifications of SEQ ID NO:
- 92 or 289.
Dependencies are inferred from the claim text.