Compositions and methods for enhancing an immune response
AssigneeThe Johns Hopkins University
InventorsTzyy-Choou Wu, Chih-Ping Mao, Chien-Fu Hung
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Abstract
The disclosure features compounds comprising an antigen portion, a soluble Major Histocompatibility Complex (MHC) molecule portion (e.g., all or an antigen-binding portion of a soluble MHC class I molecule), and a dynamic anchor portion (e.g., an agent, such as Annexin V, that binds to phosphatidylserine). The featured compounds are useful for a variety of therapeutic applications, including, e.g., enhancing a T cell response to an antigen of interest or enhancing a T cell-driven immune response by a subject to an antigen of interest (e.g., a cancer antigen or a microbial antigen).
Claims13
A compound comprising:
- (a) a soluble Major Histocompatibility Complex (MHC) molecule;
- and (b) a dynamic anchor comprising Annexin V, wherein the MHC molecule comprises a class I MHC alpha chain comprising the amino acid sequence set forth in SEQ ID NO:
- 17 or SEQ ID NO:
- 18, and a β-2 microglobulin polypeptide comprising the sequence set forth in SEQ ID NO:
- 5 or SEQ ID NO:
- 6, and
- wherein the dynamic anchor comprises the amino acid sequence depicted in SEQ ID NO:
- 1 or 2.
Dependencies are inferred from the claim text.