Malonate transporters
AssigneeCB Therapeutics, Inc.
InventorsErin Marie Scott, Jacob Michael Vogan
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Abstract
The methods and systems disclose enzymes that function to import malonic acid or malonates into a cell. The enzymes increase the output of precursor molecules by enriching certain pathways in the cell. The precursor molecules can be converted to cannabinoids. The enzymes are a family of proteins which have a majority of common alignments.
Claims13
A genetically modified microbial cell comprising at least one polypeptide that is non-naturally occurring in the cell and that allows for production of a terpene in the genetically modified microbial cell, and at least one malonate transporter gene that is non-naturally occurring in the cell, wherein the non-naturally occurring polypeptide comprises at least one enzyme selected from the group consisting of aromatic prenyltransferase (CBGAS), tetrahydrocannabiolicacid (THCA) synthase, cannabidiolic acid (CBDA) synthase, cannabichromenic acid (CBCA) synthase, aromatic prenyltransferase, malonyl CoA synthase, PKS olivetolic acid synthase and PKS olivetol synthase.
Dependencies are inferred from the claim text.