Back to results
US 11,987,551 B2Granted
Styryl carboxylate derivatives
OwnerBishwajit Nag, Ananda Sen +3inventors
InventorsBishwajit Nag, Ananda Sen, Nitish Nag, Arjun Sanyal, Srinivasan Narasimhan
Life of this patent
Estimating the term…
Abstract
Novel Styryl Carboxylate derivatives are provided which exhibit activity for the treatment of immunological diseases, inflammation, obesity, hyperlipidemia, hypertension, neurological diseases, and diabetes.
Claims16
A compound of Formula (I)
- wherein R1, R2, R3, R4, R5, R6 and R8, X and Y are hydrogens, and R7 is —C═N—OH, wherein the compound is 3-Phenyl-acrylic acid 4-(hydroxyimino-methyl)-phenyl ester, having the chemical formula as follows:
- or a pharmaceutically acceptable salt thereof.
A method for inducing a physiological effect in a subject, the physiological effect selected from the group consisting of:
- reducing the body weight of said subject, reducing fasting blood glucose in said subject, reducing cholesterol in the plasma of said subject, is reducing triglyceride levels in plasma of said subject, increasing the level of high density lipoprotein (HDL) in plasma of said subject, decreasing the level of low-density lipoproteins (LDL) in plasma of said subject, decreasing the systolic blood pressure and diastolic blood pressure of said subject, and decreasing the level of TNF-α in the plasma in said subject;
- wherein the method comprises administering to said subject a composition comprising an effective amount of phenyl-acrylic acid 4-(hydroxyimino-methyl)-phenyl ester, having the chemical formula as follows:
- or a pharmaceutically acceptable salt thereof.
A compound of Formula (I) comprising the following structure
- wherein R1, R2, R3, R4, R5 and R8, X and Y are hydrogens,
- R7 is —C═N—OH
- and R6 a methoxy group;
- wherein the compound is 3-Phenyl-acrylic acid 4-(hydroxyimino-methyl)-2-methoxy-phenyl ester, having the chemical formula as follows:
- and pharmaceutically acceptable salts thereof.
2 more elements
A method for inducing a physiological effect in a subject, wherein the physiological effect is selected from the group consisting of:
- a decrease in body weight of said subject and a decrease in the level of fasting blood glucose in said subject;
- wherein the method comprises administering to said subject a composition comprising an effective amount of 3-Phenyl-acrylic acid 4-(hydroxyimino-methyl)-2-methoxy-phenyl ester, having the chemical formula as follows:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.