Polycyclic carbogenic molecules and uses thereof as anti-cancer agents
AssigneeNorthwestern University
InventorsRegan J. Thomson, Emily E. Robinson
Life of this patent
Estimating the term…
Abstract
Disclosed are new polycyclic carbogenic molecules and their methods of synthesis. The new polycyclic carbogenic molecules may be utilized in anti-cancer therapies. In particular, the polycyclic carbogenic molecules may be formulated as pharmaceutical compositions that comprise the small molecules, which compositions may be administered in methods of treating and/or preventing cell proliferative diseases and disorders such as cancer. The new polycyclic carbogenic molecules may be prepared from vinyl- or allyl-substituted cyclohexenone precursors via preparation of a silyl bis-enol ether intermediate.
Claims17
A method for treating a cell proliferative disease or disorder in a subject in need thereof, the method comprising administering a pharmaceutical composition to the subject,
- wherein the pharmaceutical composition comprises a compound having Formula I, or a salt, solvate, or epoxide thereof, and a pharmaceutical carrier:
- wherein:
- is a single or double bond,
- m and n are selected from 0 or 1;
- and
- each occurrence of R1, R2, R3, R4, R5, R6, R7, and R8 is independently selected from hydrogen, alkyl, dialkyl, hydroxyl, protected hydroxyl, alkoxy, alkyl-alkoxy, alkyl-dialkoxy, and acetyl;
- or R3 and R5 together form an epoxide and R4 and R6 together from an epoxide;
- or R7 and R8 together from an epoxide.
A method for treating a cell proliferative disease or disorder in a subject in need thereof, the method comprising administering a pharmaceutical composition to the subject,
- wherein the pharmaceutical composition comprises a compound, or a salt or solvate thereof, and a pharmaceutical carrier and
- wherein the compound has a formula selected from:
Dependencies are inferred from the claim text.