Processes and systems for producing and/or purifying gallium-68
AssigneeSociéTé De Commercialisation Des Produits De La Recherche AppliquéE Socpra Sciences Santé Et Humaines S.E.C.
InventorsBrigitte Guerin, Sebastien Tremblay, Samia Ait-Mohand, Aiman H. Alnahwi
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Abstract
The present disclosure relates processes and systems for producing and/or purifying 68Ga from an irradiated substrate of 68Zn. In some embodiments, the process rely on the use two cation-exchange chromatography columns to separate 68Ga from 68Zn and other radionuclides and metallic impurities. The process achieves a high overall yield of 68Ga and a high effective molar activity while being implementable in a time compatible with the short half-life of 68Ga. In additional embodiments, the process is implemented by an automated system.
Claims11
A process for purifying 68Ga produced by cyclotron, the process comprising the steps of:
- (a) providing a solution comprising a mixture of 68Zn and 68Ga;
- (b) contacting the solution with a first chelating cation exchange column, the first chelating cation exchange column comprising a hydroxamate resin;
- (c) washing the first chelating cation exchange column obtained after step (b) to obtain a washed first chelating cation exchange column;
- (d) eluting the 68Ga from the washed first chelating cation exchange column to obtain a first eluent;
- (e) contacting the first eluent with a second copolymeric cation exchange column, the second copolymeric cation exchange column comprising a resin;
- (f) washing the second copolymeric cation exchange column after step (e) to obtain a washed second copolymeric cation exchange column;
- and
- (g) eluting the 68Ga from the washed second copolymeric cation exchange column to obtain a second eluent comprising purified 68Ga.
Dependencies are inferred from the claim text.