Disposable bioreactor systems and related methods
AssigneeFinesse Solutions, Inc.
InventorsMark D. Selker, Barbara Paldus
Life of this patent
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Abstract
A method for enhancing mixing and aeration of a liquid reaction medium in a toroidal bioreactor vessel includes dispensing a liquid reaction medium into an interior of a toroidal bioreactor vessel, the interior being bounded by an inner surface, a textured surface being arranged on at least a portion of the inner surface, the textured surface having a plurality of upstanding protuberances. The toroidal bioreactor vessel is rotated in an orbital motion such that there is a resonant frequency traveling wave of the fluid orbiting in one direction in the interior of the toroidal bioreactor vessel when a particular orbital speed is imparted to the toroidal bioreactor vessel.
Claims12
An apparatus comprising:
- (a) a hollow toroidal bioreactor vessel having an interior bounded by an inner surface, a textured surface being arranged on at least a portion of the inner surface, the textured surface having a sinusoidal shape pattern and being comprised of a plurality of upstanding protuberances, the toroidal bioreactor vessel further comprising a plurality of tubes coupled to at least a portion of the inner surface of the toroidal bioreactor vessel, wherein the plurality of tubes are configured for sparging gas into said toroidal bioreactor vessel, wherein one or more of the plurality of tubes is coupled to one or more of a bottom, a top, or a side-wall of the toroidal bioreactor vessel;
- and
- (b) a drive including a motor driven platform, wherein when the toroidal bioreactor vessel rests on the motor driven platform and a fluid is disposed within the interior of the toroidal bioreactor vessel, the drive is configured to move the platform orbitally such that there is a resonant frequency traveling wave of the fluid orbiting in one direction in the interior of the toroidal bioreactor vessel when a particular orbital speed is imparted to the toroidal bioreactor vessel, and
- wherein the orbiting direction of the traveling wave of the fluid is parallel to a direction of periodic oscillation of the sinusoidal shape pattern of the textured surface,
- wherein at least some of the plurality of tubes extend through the plurality of upstanding protuberances of the textured surface.
An apparatus comprising:
- (a) a hollow bioreactor vessel comprising:
- an interior bounded by an inner surface;
- a textured surface arranged on the inner surface, the textured surface comprising a plurality of upstanding protuberances;
- and
- a plurality of tubes coupled to the inner surface and extending through the plurality of upstanding protuberances of the textured surface, the plurality of tubes being configured for sparging a gas into the interior of the bioreactor vessel;
- and
- (b) a drive including a motor driven platform, the bioreactor vessel being disposed on the motor driven platform, the drive being configured to move the platform orbitally.
Dependencies are inferred from the claim text.